Irena Martin-Kleiner et al.
Cell biochemistry and function, 26(8), 916-919 (2008-10-23)
NEP/CALLA or CD10 is an endopeptidase (E.C. 188.8.131.52) that inactivates numerous neuropeptides, including dynorphin. Dynorphin is an endogenous opioid polypeptide that binds to kappa-opioid receptors with greatest affinity. R1.1 mouse thymoma cells highly express kappa-opioid receptors. In this study, on...
Benoit Gautier et al.
Chemistry & biology, 18(12), 1631-1639 (2011-12-27)
Protein-protein interactions play a central role in medicine, and their modulation with small organic compounds remains an enormous challenge. Because it has been noted that the macromolecular complexes modulated to date have a relatively pronounced binding cavity at the interface...
O L Voronova et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(10), 37-39 (2011-01-25)
Beginning with the first hours of experiments, cisplatin evoked an increase of chromosomal aberrations in CBA/CaLac bone marrow cells. Significant increase of structural infringements of chromosomes due to chromatid breaks was revealed in metaphase plates of murine bone marrow preparations...
V I Smol'iakova et al.
Eksperimental'naia i klinicheskaia farmakologiia, 74(8), 37-40 (2012-01-12)
A hepatoprotective effect of thiophan was studied on the model of carbon tetrachloride-induced hepatitis in rats. Therapeutic administration of thiophan repairs the antitoxic function of liver, normalizes cytolysis marker activity, and improves the synthetic function of liver and the carbohydrate...
The ganglionic blocking action of thiophanium derivatives.
L O RANDALL et al.
The Journal of pharmacology and experimental therapeutics, 97(1), 48-57 (1949-09-01)