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822855

TSKgel® SuperSW mAb HTP HPLC Column

phase diol, L × I.D. 15 cm × 4.6 mm, 4 μm particle size

Synonym(s):
TSKgel Size Exclusion (SW-Type) HPLC Column
Pricing and availability is not currently available.

mfr. no.

Tosoh SuperSW mAb HTP, 22855

parameter

≤0.5 M salt concentration
0-100% aqueous soluble organic solvents
0.5 mL/min flow rate
10-30 °C temperature
80 bar max. pressure

application(s)

HPLC: suitable

L × I.D.

15 cm × 4.6 mm

matrix

silica particle platform

matrix active group

diol phase

particle size

4 μm

pore size

250 Å pore size

operating pH

2.5 - 7.5

suitability

suitable for L20 per USP
suitable for L59 per USP

separation technique

size exclusion (SEC)

General description

The TSKgel SuperSW and UltraSW mAb columns consist of three specialized columns designed for the separation and analysis of monoclonal antibodies (mAb). While mAbs can be analyzed using many different modes of HPLC, size exclusion is best for aggregation, dimer, and fragmentation, making it the best method for heterogeneity studies.TSKgel SuperSW mAb HTP columns provide high throughput analysis of mAb monomer and dimer and is UHPLC compatible. These short, narrow bore (15 cm x 4.6 mm ID) silica-based stainless steel columns offer reduced lot-to-lot variation, long column life, reduction of unspecified adsorption, and superior recovery of aggregates. The TSKgel SW mAb HTP columns utilize a unique pore-controlled technology, which produces a shallow calibration curve in the molecular weight region of a typical monoclonal antibody.

Physical form

Shipped in 0.05% NaN3 and 0.1 M Na2SO4 in 0.1 M phosphate buffer, pH 6.7.

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Legal Information

TSKgel is a registered trademark of Tosoh Corporation
Certificate of Analysis
Certificate of Origin
Articles
Size-exclusion chromatography (SEC) columns and ready-to-use standards facilitate method development and increase robustness of protein SEC methods.
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