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United States Pharmacopeia (USP) Reference Standard

Aspirin, 2-Acetoxybenzoic acid, Acetylsalicylic acid, ASA, O-Acetylsalicylic acid
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CAS Number:
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PubChem Substance ID:


pharmaceutical primary standard




134-136 °C (lit.)


pharmaceutical (small molecule)



SMILES string




InChI key


Gene Information

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.


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Signal Word


Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids



Flash Point(F)

482.0 °F

Flash Point(C)

250 °C

Certificate of Analysis

Certificate of Origin

Laurent Arnaud et al.
Autoimmunity reviews, 13(3), 281-291 (2013-11-06)
We performed a meta-analysis to determine whether aspirin has a significant protective effect on risk of first thrombosis among patients with antiphospholipid antibodies (aPL+). Observational and interventional studies identified from the Medline, Embase and Cochrane databases were selected if they
Ahmed Kayssi et al.
Journal of vascular surgery, 60(1), 106-110 (2014-03-25)
Acute limb ischemia (ALI) in pediatric patients is rare but may lead to limb loss and life-long complications. This study reviewed the experience of a Canadian tertiary pediatric center with the medical and operative management of ALI. The medical records of
P J Devereaux et al.
The New England journal of medicine, 370(16), 1494-1503 (2014-04-01)
There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. Using a 2-by-2 factorial trial design, we randomly assigned
Rickard Ljung et al.
International journal of cancer, 135(1), 238-241 (2013-12-19)
Anticoagulant treatment might enhance the natural defense against tumor cell dissemination caused by diagnostic needle biopsy by counteracting thrombocyte coating of such cells. To clarify whether women using anticoagulant treatment at the time of biopsy have a lower occurrence of
Naomi Gronich et al.
Nature reviews. Clinical oncology, 10(11), 625-642 (2013-10-02)
Cancer risk reduction using pharmacological means is an attractive modern preventive approach that supplements the classical behavioural prevention recommendations. Medications that are commonly used by large populations to treat a variety of common, non-cancer-related, medical situations are an attractive candidate


HPLC Analysis of Pain Relievers on Ascentis® Express C18

Separation of Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder; Caffeine, meets USP testing specifications, anhydrous; Benzoic acid, meets USP testing specifications; Aspirin, meets USP testing specifications


HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide

Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%

HPLC Analysis of Salicylic Acid and Acetylsalicylic Acid (Aspirin) on Ascentis® Express OH5

Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)

HPLC Analysis of Benzoic Acid and Related Compounds on Ascentis® RP-Amide

Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate

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