100633

Sigma-Aldrich

1-(2-Hydroxyphenyl)-3-phenyl-2-propenone

98%

Synonym(s):
2′-Hydroxychalcone, 2-Hydroxybenzalacetophenone
Linear Formula:
C6H5CH=CHCOC6H4OH
CAS Number:
Molecular Weight:
224.25
Beilstein/REAXYS Number:
976324
EC Number:
MDL number:
PubChem Substance ID:

assay

98%

mp

86-88 °C (lit.)

SMILES string

Oc1ccccc1C(=O)\C=C\c2ccccc2

InChI

1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+

InChI key

AETKQQBRKSELEL-ZHACJKMWSA-N

Gene Information

human ... IL1B(3553)
rat ... Alox5(25290)

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Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
Sang Hoon Jung et al.
Chemical & pharmaceutical bulletin, 54(3), 368-371 (2006-03-02)
Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-gamma transactivation potential, while the others showed antagonistic activity against PPAR-gamma transactivation. Among the chalcones...
Huan Cong et al.
Journal of the American Chemical Society, 132(21), 7514-7518 (2010-05-07)
Metal nanoparticles are currently being employed as catalysts for a number of classical chemical transformations. In contrast, identification of novel reactions of nanoparticles, especially toward the synthesis of complex natural products and derivatives, is highly underdeveloped and represents a bourgeoning...
Jan F Stevens et al.
Chemical research in toxicology, 16(10), 1277-1286 (2003-10-21)
Prenylated 2'-hydroxychalcones and flavanones from the inflorescences of the female hop plant (Humulus lupulus) were shown to inhibit peroxynitrite-mediated oxidation of low-density lipoproteins (LDL) at low micromolar concentrations. LDL oxidation was induced by the peroxynitrite generator, 3-morpholinosydnonimine (SIN-1), and measured...
K Zhang et al.
Biochemical pharmacology, 52(10), 1631-1638 (1996-11-22)
The formation of dinitrophenylglutathione (DNP-SG) in human colon adenocarcinoma cells was identified and quantified by an HPLC-UV method, following exposure to 1-chloro-2,4-dinitrobenzene (CDNB) at 10 degrees for 40 min. The rate of efflux of DNP-SG at 37 degrees likewise, was...
Microwave-assisted reaction of 2'-hydroxychalcones with hydrazides to synthesize flavanone hydrazone and 4,5-dihydropyrazole derivatives.
Aihua Nie et al.
Journal of combinatorial chemistry, 8(5), 655-658 (2006-09-12)

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