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104493

Sigma-Aldrich

Chloroacetyl chloride

98%

Synonym(s):

Chloroacetic chloride

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About This Item

Linear Formula:
ClCH2COCl
CAS Number:
Molecular Weight:
112.94
Beilstein/REAXYS Number:
605439
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

$30.49

List Price$32.10Save 5%
Web-Only Promotion

Estimated to ship onJune 23, 2025Details


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vapor density

3.9 (vs air)

Quality Level

vapor pressure

60 mmHg ( 41.5 °C)

assay

98%

refractive index

n20/D 1.453 (lit.)

bp

105-106 °C (lit.)

mp

−22 °C (lit.)

density

1.418 g/mL at 25 °C (lit.)

functional group

acyl chloride
chloro

SMILES string

ClCC(Cl)=O

InChI

1S/C2H2Cl2O/c3-1-2(4)5/h1H2

InChI key

VGCXGMAHQTYDJK-UHFFFAOYSA-N

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1 of 4

This Item
22880D550088.02411
assay

98%

assay

≥99.0% (GC)

assay

98%

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

refractive index

n20/D 1.453 (lit.)

refractive index

n20/D 1.453 (lit.)

refractive index

n20/D 1.46 (lit.)

refractive index

-

mp

−22 °C (lit.)

mp

−22 °C (lit.)

mp

-

mp

-22.5 °C

density

1.418 g/mL at 25 °C (lit.)

density

1.419 g/mL at 20 °C, 1.418 g/mL at 25 °C (lit.)

density

1.532 g/mL at 25 °C (lit.)

density

1.417 g/cm3 at 20 °C

bp

105-106 °C (lit.)

bp

105-106 °C (lit.)

bp

107-108 °C (lit.)

bp

105-110 °C/1013 hPa

General description

Chloroacetyl chloride is used as a chlorinating agent, acylating agent, precursor to monochloroketene, and as a building block for cyclization.[1]

Chloroacetyl chloride causes the acylation of cyano-pyrazoline during the synthesis of secondary amine-substituted cyano-pyrazoline derivatives[2].

Application

Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate)[3]. Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes[4]. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity[5].

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1

target_organs

Lungs

supp_hazards

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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