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104493

Sigma-Aldrich

Chloroacetyl chloride

98%

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Synonym(s):
Chloroacetic chloride
Linear Formula:
ClCH2COCl
CAS Number:
Molecular Weight:
112.94
Beilstein/REAXYS Number:
605439
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.9 (vs air)

Quality Level

vapor pressure

60 mmHg ( 41.5 °C)

assay

98%

refractive index

n20/D 1.453 (lit.)

bp

105-106 °C (lit.)

mp

−22 °C (lit.)

density

1.418 g/mL at 25 °C (lit.)

SMILES string

ClCC(Cl)=O

InChI

1S/C2H2Cl2O/c3-1-2(4)5/h1H2

InChI key

VGCXGMAHQTYDJK-UHFFFAOYSA-N

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1 of 4

This Item
22880D55008545694
Chloroacetyl chloride 98%

104493

Chloroacetyl chloride

Chloroacetyl chloride purum, ≥99.0% (GC)

22880

Chloroacetyl chloride

Dichloroacetyl chloride 98%

D55008

Dichloroacetyl chloride

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

refractive index

n20/D 1.453 (lit.)

refractive index

n20/D 1.453 (lit.)

refractive index

n20/D 1.46 (lit.)

refractive index

-

bp

105-106 °C (lit.)

bp

105-106 °C (lit.)

bp

107-108 °C (lit.)

bp

-

mp

−22 °C (lit.)

mp

−22 °C (lit.)

mp

-

mp

55-58 °C (lit.)

density

1.418 g/mL at 25 °C (lit.)

density

1.419 g/mL at 20 °C, 1.418 g/mL at 25 °C (lit.)

density

1.532 g/mL at 25 °C (lit.)

density

-

General description

Chloroacetyl chloride is used as a chlorinating agent, acylating agent, precursor to monochloroketene, and as a building block for cyclization.

Chloroacetyl chloride causes the acylation of cyano-pyrazoline during the synthesis of secondary amine-substituted cyano-pyrazoline derivatives.

Application

Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate). Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1

target_organs

Lungs

supp_hazards

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Chloroacetyl Chloride
George AO, et al.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
S Coleman et al.
Environmental health perspectives, 108(12), 1151-1157 (2001-01-03)
Acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)-acetamide], alachlor [N-(methoxymethyl)-2-chloro-N-(2, 6-diethyl-phenyl)acetamide], butachlor [N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-phenyl)acetamide], and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] are pre-emergent herbicides used in the production of agricultural crops. These herbicides are carcinogenic in rats: acetochlor and alachlor cause tumors in the nasal turbinates, butachlor causes stomach tumors
Kenawy el-R et al.
Journal of controlled release : official journal of the Controlled Release Society, 50(1-3), 145-152 (1998-08-01)
Polymers with antibacterial activity have been synthesized by chemical modification of poly(glycidyl methacrylate). The glycidyl methacrylate was polymerized by the free radical polymerization technique. The poly(glycidyl methacrylate) was hydrolyzed and was chloroacetylated using chloroacetyl chloride. The chloroacetylated product was modified
Niranjan P Sahu et al.
Bioorganic & medicinal chemistry, 10(6), 1687-1693 (2002-04-09)
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver
[Three cases of acute chloroacetyl chloride poisoning].
Jian-Fang Zou et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 26(10), 600-600 (2009-03-11)

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