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107271

(±)-3-Chloro-1,2-propanediol

98%

Synonym(s):

α-Chlorohydrin, α-Glycerol chlorohydrin, α-Monochlorohydrin, 3-MCPD

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$59.20

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$85.60

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About This Item

Linear Formula:
ClCH2CH(OH)CH2OH
CAS Number:
96-24-2
Molecular Weight:
110.54
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24846761
EC Number:
202-492-4
Beilstein/REAXYS Number:
635684
MDL number:
MFCD00004712
Assay:
98%

Key Documents

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InChI key

SSZWWUDQMAHNAQ-UHFFFAOYSA-N

InChI

1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2

SMILES string

OCC(O)CCl

vapor pressure

0.04 mmHg ( 25 °C)

assay

98%

Quality Level

100

refractive index

n20/D 1.480 (lit.)

bp

213 °C (lit.)

solubility

H2O: soluble, alcohol: soluble, diethyl ether: soluble

density

1.322 g/mL at 25 °C (lit.)

functional group

chloro, hydroxyl

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1 of 4

This Item
3240636295540064
(±)-3-Chloro-1,2-propanediol 98%

Sigma-Aldrich

107271

(±)-3-Chloro-1,2-propanediol

(±)-3-Chloro-1,2-propanediol analytical standard

Supelco

32406

(±)-3-Chloro-1,2-propanediol

2,3-Dichloro-1-propanol ≥97.0% (GC)

Sigma-Aldrich

36295

2,3-Dichloro-1-propanol

(S)-(+)-3-Chloro-1,2-propanediol 97%, optical purity ee: 97% (GLC)

Sigma-Aldrich

540064

(S)-(+)-3-Chloro-1,2-propanediol

assay

98%

assay

-

assay

≥97.0% (GC)

assay

97%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble, diethyl ether: soluble, alcohol: soluble

solubility

-

solubility

-

solubility

-

bp

213 °C (lit.)

bp

213 °C (lit.)

bp

-

bp

213 °C (lit.)

density

1.322 g/mL at 25 °C (lit.)

density

1.322 g/mL at 25 °C (lit.)

density

1.360 g/mL at 20 °C (lit.)

density

1.322 g/mL at 25 °C (lit.)

refractive index

n20/D 1.480 (lit.)

refractive index

n20/D 1.480 (lit.)

refractive index

-

refractive index

n20/D 1.480 (lit.)

General description

3-Chloro-1,2-propanediol undergoes enantioselective transformation to (R)-3-chloro-1,2-propanediol by the cell extract of Corynebacterium sp. strain N-1074 [1]. It is a contaminant found in food in free (diol) form as well as in an esterified (with fatty acids) form[2].

Application

(±)-3-Chloro-1,2-propanediol may be used in manufacture of dye intermediates.

Biochem/physiol Actions

3-Chloro-1,2-propanediol is a potent rodent chemosterilant[3].

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 1 - STOT SE 1

target_organs

Kidney, Testes

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP3271
BCCN6506
BCCM0791
BCCM3803
BCCL4568

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Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats.
E Samojlik et al.
Biology of reproduction, 2(2), 299-304 (1970-04-01)
T Nakamura et al.
Journal of bacteriology, 174(23), 7613-7619 (1992-12-01)
During the course of the transformation of 1,3-dichloro-2-propanol (DCP) into (R)-3-chloro-1,2-propanediol [(R)-MCP] with the cell extract of Corynebacterium sp. strain N-1074, epichlorohydrin (ECH) was transiently formed. The cell extract was fractionated into two DCP-dechlorinating activities (fractions Ia and Ib) and
W Seefelder et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 391-400 (2008-03-19)
3-Mono-chloropropane-1,2-diol (3-MCPD) is a contaminant that occurs in food in its free (diol) form as well as in an esterified (with fatty acids) form. Using a simple intestinal model, it was demonstrated that 3-MCPD monoesters and 3-MCPD diesters are accepted
Ching-Yu Lin et al.
Reproductive toxicology (Elmsford, N.Y.), 28(1), 75-80 (2009-06-06)
Sperm ATP is derived primarily from either glycolysis or mitochondrial oxidative phosphorylation. In the present studies, (1)H NMR spectroscopy was used to characterize the metabolite profile in primate sperm treated either with alpha-chlorohydrin (ACH), a known inhibitor of sperm glycolysis
Z Zelinková et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(6), 669-676 (2008-05-20)
A series of twelve breast milk samples were analysed by gas chromatography-mass spectrometry (GC/MS) operated in selected ion monitoring mode for 3-chloropropane-1,2-diol (3-MCPD). Whilst none of the samples contained 3-MCPD above the limit of detection of 3 microg kg(-1) milk
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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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