108057

Sigma-Aldrich

Methyl phenylacetate

ReagentPlus®, ≥99%

Linear Formula:
C6H5CH2CO2CH3
CAS Number:
Molecular Weight:
150.17
Beilstein/REAXYS Number:
878795
EC Number:
MDL number:
PubChem Substance ID:

product line

ReagentPlus®

Quality Level

assay

≥99%

refractive index

n20/D 1.503 (lit.)

bp

218 °C (lit.)

density

1.066 g/mL at 20 °C (lit.)

SMILES string

COC(=O)Cc1ccccc1

InChI

1S/C9H10O2/c1-11-9(10)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChI key

CRZQGDNQQAALAY-UHFFFAOYSA-N

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Application

Methyl phenylacetate was used as model compound for partition coefficient measurement experiments.

Packaging

100 g in glass bottle

Biochem/physiol Actions

Methyl phenylacetate undergoes decomposition on photolysis in methanol. Methyl phenylacetate acts as acylating agent and causes the enantioselective acylation of beta-lactam intermediate using penicillin G amidase. Methyl phenylacetate is the starting material in manufacture of synthetic perfumes.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

WGK Germany

WGK 2

Flash Point(F)

195.8 °F - closed cup

Flash Point(C)

91 °C - closed cup

Certificate of Analysis

Certificate of Origin

Photolysis of phenylacetic acid and methyl phenylacetate in methanol.
Meiggs TO and Miller SI.
Journal of the American Chemical Society, 94(6), 1989-1996 (1972)
Yichen Cao et al.
Journal of pharmaceutical sciences, 93(11), 2768-2779 (2004-09-25)
The ability to predict drug solubility and partitioning in triglyceride solvents from the chemical structures of the solute and the triglyceride would be highly useful in drug formulation development and in screening drug candidates for lipid solubility and possibly drug...
Enantioselective acylation of a beta-lactam intermediate in the synthesis of loracarbef using penicillin G amidase.
Zmijewski Jr MJ, et al.
Tetrahedron Letters, 32(13), 1621-1622 (1991)
Miriam Frida Karlsson et al.
Journal of agricultural and food chemistry, 57(13), 5903-5909 (2009-06-06)
The Guatemalan moth Tecia solanivora is an invasive pest of potato in Central and South America. The larvae infest potato tubers in the field as well as in storage facilities. The headspace of potato foliage and potato tubers was studied...
Jonathan Slaughter et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(1), 167-175 (2016-10-30)
In investigating and seeking to mimic the reactivity of trimethylaluminium (TMA) with synthetic, ester-based lubricating oils, the reaction of methyl propionate 1 was explored with 1, 2 and 3 equivalents of the organoaluminium reagent. Spectroscopic analysis points to the formation of...

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