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108448

Sigma-Aldrich

Cyanoacetamide

99%

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Synonym(s):
2-Cyanoacetamide
Linear Formula:
NCCH2CONH2
CAS Number:
Molecular Weight:
84.08
Beilstein:
878221
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

99%

mp

119-121 °C (lit.)

solubility

cold water: soluble 1gm in 6.5ml

SMILES string

NC(=O)CC#N

InChI

1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)

InChI key

DGJMPUGMZIKDRO-UHFFFAOYSA-N

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This Item
12305682870319899
Cyanoacetamide 99%

Sigma-Aldrich

108448

Cyanoacetamide

Anthrone ACS reagent, 97%

Sigma-Aldrich

319899

Anthrone

mp

119-121 °C (lit.)

mp

28-31 °C (lit.)

mp

140-143 °C (lit.)

mp

154-157 °C (lit.)

solubility

cold water: soluble 1gm in 6.5ml

solubility

-

solubility

-

solubility

ethyl acetate: 2%, clear, yellow

General description

Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions.

Application

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

419.0 °F - closed cup

Flash Point(C)

215 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Cyanoacetamide derivatives as synthons in heterocyclic synthesis
Fadda, et al.
Turkish Journal of Chemistry, 32, 259-286 (2008)
Cyanoacetamide derivatives as synthons in heterocyclic synthesis.
Fadda AA, et al.
Turkish Journal of Chemistry, 32(3), 259-286 (2008)
Gregg A Duncan et al.
Molecular therapy. Methods & clinical development, 9, 296-304 (2018-07-25)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we
Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids.
Ibrahim F, et al.
International Journal of Pharmaceutical Sciences and Research, 2(8), 2056-2072 (2011)
Synthesis of new 3-cyanoacetamide pyrrole and 3-acetonitrile pyrrole derivatives
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Articles

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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