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108448

Sigma-Aldrich

Cyanoacetamide

99%

Synonym(s):

2-Cyanoacetamide

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$64.60
500 G
$207.00

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100 G
$64.60
500 G
$207.00

About This Item

Linear Formula:
NCCH2CONH2
CAS Number:
107-91-5
Molecular Weight:
84.08
Beilstein/REAXYS Number:
878221
EC Number:
203-531-8
MDL number:
MFCD00008024
UNSPSC Code:
12352100
PubChem Substance ID:
24846668
NACRES:
NA.22

$64.60

Available to ship onApril 22, 2025Details

Request a Bulk Order

Quality Level

200

assay

99%

mp

119-121 °C (lit.)

solubility

cold water: soluble 1gm in 6.5ml

functional group

amide
nitrile

SMILES string

NC(=O)CC#N

InChI

1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)

InChI key

DGJMPUGMZIKDRO-UHFFFAOYSA-N

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General description

Cyanoacetamide is the starting reagent for vitamin B6 synthesis[1]. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes[2].

Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions. [3] [4]

Application

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride[5]. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine[6]. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum[5].

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

419.0 °F - closed cup

flash_point_c

215 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3449V
WXBF0576V
WXBD6820V
WXBD4092V
WXBD1966V

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Cyanoacetamide derivatives as synthons in heterocyclic synthesis.
Fadda AA, et al.
Turkish Journal of Chemistry, 32(3), 259-286 (2008)
Gregg A Duncan et al.
Molecular therapy. Methods & clinical development, 9, 296-304 (2018-07-25)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we
Cyanoacetamide derivatives as synthons in heterocyclic synthesis
Fadda, et al.
Turkish Journal of Chemistry, 32, 259-286 (2008)
Hao Chen et al.
Scientific reports, 8(1), 13433-13433 (2018-09-09)
Early damage to transplanted organs initiates excess inflammation that can cause ongoing injury, a leading cause for late graft loss. The endothelial glycocalyx modulates immune reactions and chemokine-mediated haptotaxis, potentially driving graft loss. In prior work, conditional deficiency of the
Lionel Carles et al.
The Journal of organic chemistry, 67(12), 4304-4308 (2002-06-11)
The condensation of an enone or enal with cyanoacetamide derivatives and t-BuOK furnishes either 3-cyano-2-pyridones or 3-unsubstituted-2-pyridones, depending on whether the reaction is carried out in the presence or in the absence of O(2). In the first case, in situ
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Articles

Knoevenagel Condensation Reaction

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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