112631

2-Methoxy-4-nitroaniline

98%

• Synonym(s): 4-Nitro-o-anisidine
• Linear Formula: CH₃OC₆H₃(NO₂)NH₂
• CAS Number: 97-52-9
• Molecular Weight: 168.15
• UNSPSC Code: 12352100
• NACRES: NA.22
• PubChem Substance ID: 24847104
• EC Number: 202-588-6
• Beilstein/REAXYS Number: 879619
• MDL number: MFCD00007363
• Assay: 98%

Properties

• Quality Segment: 100
• assay: 98%
• mp: 140-142 °C (lit.)
• functional group: nitro
• SMILES string: COc1cc(ccc1N)[N+]([O-])=O
• InChI: 1S/C7H8N2O3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,8H2,1H3
• InChI key: GVBHRNIWBGTNQA-UHFFFAOYSA-N

Description

General description

2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.

Application

2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.

Biochem/physiol Actions

The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Codes: H302,H351,H411
• Precautionary Statements: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves