4,4′-Methylene-bis(2-chloroaniline)

Name: 4,4′-Methylene-bis(2-chloroaniline)
Brand: ALDRICH
Price: 143.65 USD
Availability: InStock

85%

Synonym(s):

2,2′-Dichloro-4,4′-methylenedianiline, 4,4′-Diamino-3,3′-dichlorodiphenylmethane

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About This Item

Linear Formula:

CH₂[C₆H₃(Cl)NH₂]₂

CAS Number:

101-14-4

Molecular Weight:

267.15

Beilstein/REAXYS Number:

1882318

EC Number:

202-918-9

MDL number:

MFCD00047829

UNSPSC Code:

12162002

PubChem Substance ID:

24847326

NACRES:

NA.23

Key Documents

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Quality Level

100

assay

85%

form

solid

bp

202-214 °C/0.3 mmHg (lit.)

mp

102-107 °C (lit.)

SMILES string

Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl

InChI

1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2

Inchi Key

IBOFVQJTBBUKMU-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item	360783	96738	BCR297
Sigma-Aldrich 117323 4,4′-Methylene-bis(2-chloroaniline)	Sigma-Aldrich 360783 4,4′-Methylenebis(2,6-diethylaniline)	Sigma-Aldrich 96738 (R)-(+)-5,5′-Dichloro-2,2′-bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl	BCR297 2,2′,4,4′,5,5′-Hexachlorobiphenyl (IUPAC No. 153)
assay 85%	assay 99%	assay ≥95.0% (H-NMR)	assay -
mp 102-107 °C (lit.)	mp 88-90 °C (lit.)	mp -	mp -
form solid	form solid	form crystals	form -
bp 202-214 °C/0.3 mmHg (lit.)	bp -	bp -	bp -
Quality Level 100	Quality Level -	Quality Level 100	Quality Level -

Pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H341,H350,H410

pcodes

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

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Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4'-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes.

E B Murray et al.

Reviews on environmental health, 20(3), 163-176 (2005-12-13)

Cytogenetic end-points used to estimate risk of genotoxic events in workers include the measurement of micronuclei (MN) in exfoliated cells, lymphocytes, and other tissues. Micronuclei are chromatin-containing bodies outside the cell nucleus resulting from contaminant-induced DNA damage. A review of

A critical evaluation of centromeric labeling to distinguish micronuclei induced by chromosomal loss and breakage in vitro.

M Schuler et al.

Mutation research, 392(1-2), 81-95 (1997-08-01)

The in vitro micronucleus assay in conjunction with CREST-staining and fluorescence in situ hybridization (FISH) with centromere-specific DNA probes is being increasingly utilized for the detection of clastogenic and aneuploidy-inducing agents. Although potentially powerful techniques, both methods have unique characteristics

Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4'-methylenebis (2-chloroaniline) exposure and smoking.

Hong-I Chen et al.

Journal of occupational health, 49(5), 389-398 (2007-10-24)

Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between

Simultaneous analysis of urinary 4,4'-methylenebis(2-chloroaniline) and N-acetyl 4,4'-methylenebis(2-chloroaniline) using solid-phase extraction and liquid chromatography/tandem mass spectrometry.

Wei-Chung Shih et al.

Rapid communications in mass spectrometry : RCM, 21(24), 4073-4078 (2007-11-17)

Analysis of 4,4'-methylenebis(2-cholroaniline) (MOCA) or its metabolites in urine has been considered as the appropriate method to assess MOCA exposures through inhalation and skin absorption. MOCA and its metabolite, N-acetyl 4,4'-methylenebis(2-chloroaniline) (acetyl-MOCA), are analyzed using methods either limited by sensitivity

4,4'-Methylenebis(2-chloroaniline).

Report on carcinogens : carcinogen profiles, 10, 149-151 (2004-08-26)

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4,4′-Methylene-bis(2-chloroaniline)