11970

1,3-Diphenyl-2-propenone

≥98.0% (GC)

• Synonym(s): Benzalacetophenone, Chalcone
• Linear Formula: C₆H₅CH=CHCOC₆H₅
• CAS Number: 94-41-7
• Molecular Weight: 208.26
• Beilstein: 1210466
• EC Number: 202-330-2
• MDL number: MFCD00003082
• PubChem Substance ID: 57646947
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥98.0% (GC)
• solubility: dioxane: soluble 1 g/10 mL, clear, colorless
• SMILES string: O=C(\C=C\c1ccccc1)c2ccccc2
• InChI: 1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
• InChI key: DQFBYFPFKXHELB-VAWYXSNFSA-N
• Gene Information: rat ... Ar(24208)

Description

Application

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Packaging

100, 500 g

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves