122017

Sigma-Aldrich

o-Toluoyl chloride

99%

Synonym(s):
2-Methylbenzoyl chloride
Linear Formula:
CH3C6H4COCl
CAS Number:
Molecular Weight:
154.59
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

refractive index

n20/D 1.5549 (lit.)

bp

88-90 °C/12 mmHg (lit.)

density

1.185 g/mL at 25 °C (lit.)

SMILES string

Cc1ccccc1C(Cl)=O

InChI

1S/C8H7ClO/c1-6-4-2-3-5-7(6)8(9)10/h2-5H,1H3

InChI key

GPZXFICWCMCQPF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Flash vacuum pyrolysis of o-toluoyl chloride at 780°C and 0.5 mmHg yields benzocyclobutenone.

Packaging

5, 100 g in glass bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

C

Risk Statement

34-36/37

Safety Statement

23-26-27-36/37/39-45

RIDADR

UN 3265 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

170.6 °F - closed cup

Flash Point(C)

77 °C - closed cup

Improved synthesis of benzocyclobutenone by flash vacuum pyrolysis.
Suzzarini L, et al.
Tetrahedron Letters, 39(13), 1695-1696 (1998)
Ataf Ali Altaf et al.
Dalton transactions (Cambridge, England : 2003), 47(34), 11769-11781 (2018-08-18)
Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C5H5-Fe-C5H4-C6H4-NH-CO-C6H4-R (where R = H, F, Cl, CH3 and OCH3), have been successfully synthesized. The compounds were characterized by elemental analysis and FTIR, 1H NMR and 13C NMR...
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.