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128910

Sigma-Aldrich

N,O-Bis(trimethylsilyl)acetamide

synthesis grade, ≥95%

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Synonym(s):
BSA
Linear Formula:
CH3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
10416-59-8
Molecular Weight:
203.43
Beilstein:
1306669
EC Number:
233-892-7
MDL number:
MFCD00008270
PubChem Substance ID:
24847878
NACRES:
NA.22

grade

synthesis grade

Quality Level

100

Assay

≥95%

form

liquid

refractive index

n20/D 1.417 (lit.)

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

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1 of 4

This Item
152698.187271.09649
N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%

Sigma-Aldrich

128910

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide for GC derivatization, LiChropur™, ≥98.5% (GC)

Supelco

15269

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide for synthesis

Sigma-Aldrich

8.18727

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide for gas chromatography

Supelco

1.09649

N,O-Bis(trimethylsilyl)acetamide

form

liquid

form

liquid

form

liquid

form

liquid

refractive index

n20/D 1.417 (lit.)

refractive index

n20/D 1.417 (lit.)

refractive index

-

refractive index

-

bp

71-73 °C/35 mmHg (lit.)

bp

71-73 °C/35 mmHg (lit.)

bp

43 °C/11 hPa

bp

43 °C/11 hPa

density

0.832 g/mL at 20 °C (lit.)

density

0.832 g/mL at 20 °C (lit.)

density

0.83 g/cm3 at 20 °C

density

0.83 g/cm3 at 20 °C

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

General description

N,O-Bis(trimethylsilyl)acetamide(BSA) is a powerful silylating agent for the protection of amides, amines, alcohols, carboxylic acids, enols and phenols. It can also be used as a Bronsted base precursor in Tsuji–Trost reactions. Additionally, it can be used to activate different functional groups during the production of nucleosides, peptides, and heterocycles.

Application

Derivatization reagent for GC-MS analysis of phenolic acids in fruits.
Reagent for the regioselective desulfation of polysaccharide sulfates. Also used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Features and Benefits

BSA is good moisture absorbent.

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H226 - H302 - H314

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

111.2 °F - closed cup

Flash Point(C)

44 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Carbohydrate Research, 237, 313-313 (1992)
Solvent free synthesis of 3, 4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N, O-bis (trimethylsilyl) acetamide and dicyclohexyl carbodimide
Murthy YLN, et al.
Arabian Journal of Chemistry, 9, S1740-S1746 (2016)
N, O-Bis (trimethylsilyl) acetamide
Claraz A
Synlett, 24(5), 657-658 (2013)
Mohammad Saraji et al.
Journal of separation science, 29(9), 1223-1229 (2006-07-13)
A simple analytical procedure based on single-drop microextraction combined with in-syringe derivatization and GC-MS was developed for determination of some phenolic acids in fruits and fruit juices. Cinnamic acid, o-coumaric acid, caffeic acid, and p-hydroxybenzoic acid were used as model
Olga Moiseeva et al.
Cell cycle (Georgetown, Tex.), 14(15), 2408-2421 (2015-06-02)
Expression of oncogenes or short telomeres can trigger an anticancer response known as cellular senescence activating the p53 and RB tumor suppressor pathways. This mechanism is switched off in most tumor cells by mutations in p53 and RB signaling pathways.
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