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MilliporeSigma

128910

N,O-Bis(trimethylsilyl)acetamide

synthesis grade, ≥95%

Synonym(s):

BSA

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10 ML

$69.30

25 ML

$79.90

100 ML

$134.00

1 L

$702.00

$69.30


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About This Item

Linear Formula:
CH3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
Molecular Weight:
203.43
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
EC Number:
233-892-7
Beilstein/REAXYS Number:
1306669
MDL number:
Assay:
≥95%
Form:
liquid

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Product Name

N,O-Bis(trimethylsilyl)acetamide, synthesis grade, ≥95%

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

grade

synthesis grade

assay

≥95%

form

liquid

refractive index

n20/D 1.417 (lit.)

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

functional group

amine

Quality Level

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1 of 4

This Item
152698.1872715222
assay

≥95%

assay

≥98.5% (GC)

assay

≥95.0% (GC)

assay

≥99.0% (GC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

refractive index

n20/D 1.417 (lit.)

refractive index

n20/D 1.417 (lit.)

refractive index

-

refractive index

n20/D 1.384 (lit.)

density

0.832 g/mL at 20 °C (lit.)

density

0.832 g/mL at 20 °C (lit.)

density

0.83 g/cm3 at 20 °C

density

0.969 g/mL at 25 °C (lit.)

form

liquid

form

liquid

form

liquid

form

liquid

bp

71-73 °C/35 mmHg (lit.)

bp

71-73 °C/35 mmHg (lit.)

bp

43 °C/11 hPa

bp

45-50 °C/14 mmHg (lit.)

Application

Derivatization reagent for GC-MS analysis of phenolic acids in fruits.[1]
Reagent for the regioselective desulfation of polysaccharide sulfates.[2] Also used to prepare trimethylsilyl ethers of carbohydrates and alcohols.[3]

Features and Benefits

BSA is good moisture absorbent.[4]

General description

N,O-Bis(trimethylsilyl)acetamide(BSA) is a powerful silylating agent for the protection of amides, amines, alcohols, carboxylic acids, enols and phenols. It can also be used as a Bronsted base precursor in Tsuji–Trost reactions. Additionally, it can be used to activate different functional groups during the production of nucleosides, peptides, and heterocycles.[5]

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

111.2 °F - closed cup

flash_point_c

44 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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N, O-Bis (trimethylsilyl) acetamide
Claraz A
Synlett, 24(5), 657-658 (2013)
Mohammad Saraji et al.
Journal of separation science, 29(9), 1223-1229 (2006-07-13)
A simple analytical procedure based on single-drop microextraction combined with in-syringe derivatization and GC-MS was developed for determination of some phenolic acids in fruits and fruit juices. Cinnamic acid, o-coumaric acid, caffeic acid, and p-hydroxybenzoic acid were used as model
Solvent free synthesis of 3, 4-dihydropyrimidine-2-(1H)-ones/thiones catalyzed by N, O-bis (trimethylsilyl) acetamide and dicyclohexyl carbodimide
Murthy YLN, et al.
Arabian Journal of Chemistry, 9, S1740-S1746 (2016)
Carbohydrate Research, 237, 313-313 (1992)
A novel regioselective desulfation of polysaccharide sulfates: Specific 6-O-desulfation with N,O-bis(trimethylsilyl)acetamide.
M Matsuo et al.
Carbohydrate research, 241, 209-215 (1993-03-17)

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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