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MilliporeSigma

133361

2-Naphthalenesulfonyl chloride

99%

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About This Item

Empirical Formula (Hill Notation):
C10H7ClO2S
CAS Number:
93-11-8
Molecular Weight:
226.68
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24848104
EC Number:
202-219-9
Beilstein/REAXYS Number:
641898
MDL number:
MFCD00004087

Key Documents

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Product Name

2-Naphthalenesulfonyl chloride, 99%

form

solid

InChI key

OPECTNGATDYLSS-UHFFFAOYSA-N

InChI

1S/C10H7ClO2S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H

SMILES string

ClS(=O)(=O)c1ccc2ccccc2c1

assay

99%

bp

147.7 °C/0.6 mmHg (lit.)

mp

74-76 °C (lit.)

Quality Level

200

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M7707146110C73303
2-Naphthalenesulfonyl chloride 99%

Sigma-Aldrich

133361

2-Naphthalenesulfonyl chloride

2-Mesitylenesulfonyl chloride 99%

Sigma-Aldrich

M7707

2-Mesitylenesulfonyl chloride

3,5-Dichloro-2-hydroxybenzenesulfonyl chloride 99%

Sigma-Aldrich

146110

3,5-Dichloro-2-hydroxybenzenesulfonyl chloride

2-Methylbenzyl chloride 99%

Sigma-Aldrich

C73303

2-Methylbenzyl chloride

assay

99%

assay

99%

assay

99%

assay

99%

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

mp

74-76 °C (lit.)

mp

55-57 °C (lit.)

mp

80-83 °C (lit.)

mp

-

bp

147.7 °C/0.6 mmHg (lit.)

bp

-

bp

-

bp

197-199 °C (lit.)

form

solid

form

crystals

form

-

form

liquid

Application

2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist[1]. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate[2].

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H290,H314

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1664
BCCC4085
BCBZ4853
BCBS7190V
BCBT7847

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M J Tozer et al.
Bioorganic & medicinal chemistry letters, 9(13), 1825-1830 (1999-07-16)
Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.
K Tsuji et al.
Journal of chromatography, 333(2), 365-380 (1985-10-04)
A normal-phase high-performance liquid chromatographic (HPLC) method has been developed for the assay of spectinomycin hydrochloride and spectinomycin sulfate for detection at 254 nm. The method involves pre-column derivatization of secondary amines of spectinomycin with 2-naphthalenesulfonyl chloride (NSCl) using a
K Tsuji et al.
Journal of chromatography, 369(1), 105-115 (1986-11-07)
A normal phase high-performance liquid chromatographic (HPLC) method has been developed for the assay of neomycin sulfate. The method involves pre-column derivatization with 2-naphthalenesulfonyl chloride (NSCl) followed by extraction in chloroform and chromatography using a normal phase silica column with

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