135046

Sigma-Aldrich

4-Nitrophenyl trimethylacetate

98%

Synonym(s):
4-Nitrophenyl pivalate
Linear Formula:
(CH3)3CCO2C6H4NO2
CAS Number:
Molecular Weight:
223.23
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

98%

mp

92-95 °C (lit.)

SMILES string

CC(C)(C)C(=O)Oc1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H13NO4/c1-11(2,3)10(13)16-9-6-4-8(5-7-9)12(14)15/h4-7H,1-3H3

InChI key

QADVJDGFQGNSIF-UHFFFAOYSA-N

Related Categories

General description

4-Nitrophenyl trimethylacetate undergoes hydrolysis catalysed by cytoplasmic aldehyde dehydrogenase in presence of NAD+, NADH, propionaldehyde, chloral hydrate, diethylstilboestrol and p-nitrobenzaldehyde (modifiers).

Application

4-Nitrophenyl trimethylacetate was used as sensitive probe to study the catalytic activity of carboxypeptidase Y.

Packaging

25 g in poly bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

The trimethylacetyl-transglutaminase complex.
J E Folk
Methods in enzymology, 87, 36-42 (1982-01-01)
H C Margolis et al.
The Journal of biological chemistry, 253(21), 7891-7897 (1978-11-10)
In the course of our further investigation of the active site titration of carboxypeptidase Y, using 4-nitrophenyl trimethylacetate, we have found that carboxypeptidase Y can be isolated in different molecular forms. Carboxypeptidase Y obtained from Fleischmann baker's yeast has a...
Studies of the esterase activity of cytosolic aldehyde dehydrogenase using sterically hindered and cyclic substrates.
K E Kitson et al.
Advances in experimental medicine and biology, 372, 45-52 (1995-01-01)
T M Kitson
The Biochemical journal, 257(2), 573-578 (1989-01-15)
The effects of modifiers (NAD+, NADH, propionaldehyde, chloral hydrate, diethylstilboestrol and p-nitrobenzaldehyde) on the hydrolysis of p-nitrophenyl (PNP) pivalate (PNP trimethylacetate) catalysed by cytoplasmic aldehyde dehydrogenase are reported. In each case a different inhibition pattern is obtained to that observed...
Roall Espersen et al.
Applied microbiology and biotechnology, 104(6), 2513-2522 (2020-01-29)
Two proteases, named C- and T-like proteases, respectively, were purified from the culture supernatant of Amycolatopsis keratinophila subsp. keratinophila D2T grown on a keratinous slaughterhouse by-product of pig bristles and nails as sole nitrogen and carbon source. The two proteases...

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