technical grade

Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:
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technical grade

Quality Level


2% 2-pyrrolidinone

refractive index

n20/D 1.5 (lit.)


120-123 °C/1 mmHg (lit.)


1.014 g/mL at 25 °C (lit.)

SMILES string




InChI key


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General description

N-(3-Aminopropyl)-2-pyrrolidinone (PYR) conjugates (VPA-PYR) of valproic acid (VA) have been investigated for their anticonvulsant activity in mice. It is the γ-lactam form of isoputreanine.


N-(3-Aminopropyl)-2-pyrrolidinone was used in the simultaneous determination of total polyamines and three of their non−α− amino acid metabolites in urine by capillary gas-chromatographic method with nitrogen-phosphorus detection.


5, 25 g in glass bottle

Other Notes

Contains varying amounts of 1,5-diazabicyclo4.3.0non-5-ene (cat. no. 136581)



Signal Word


Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes


Risk Statement


Safety Statement



UN 3267 8 / PGII

WGK Germany


Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Ofer Spiegelstein et al.
Epilepsy research, 57(2-3), 145-152 (2004-03-12)
Valproic acid (VPA) is an effective antiepileptic medication, the use of which in females of childbearing age is complicated by its ability to induce birth defects, including neural tube defects (NTDs), in exposed embryos. In experimental settings, VPA reproducibly induces...
N Seiler et al.
The Biochemical journal, 208(1), 189-197 (1982-10-15)
A high-pressure-liquid-chromatographic method suitable for the separation and sensitive detection of putreanine and isoputreanine is described. This method allowed us to study the formation of the metabolites of the oxidative deamination of spermidine and N1-acetylspermidine. Administration of spermidine trishydrochloride to...
Andre P Martinez et al.
Biomacromolecules, 18(6), 2000-2011 (2017-05-20)
A series of biodegradable drug delivery polymers with intrinsic multifunctionality have been designed and synthesized utilizing a polyphosphazene macromolecular engineering approach. Novel water-soluble polymers, which contain carboxylic acid and pyrrolidone moieties attached to an inorganic phosphorus-nitrogen backbone, were characterized by...
N Seiler et al.
The International journal of biochemistry, 15(7), 907-915 (1983-01-01)
Normal human and rat urine contain N-(3-aminopropyl)pyrrolidin-2-one. This compound was identified by its chromatographic behaviour on a reversed phase column, by thin-layer chromatography of its dansyl derivative, and by mass spectrometry. Evidence for the presence of conjugates of N-(3-aminopropyl)pyrrolidin-2-one in...
F A Muskiet et al.
Clinical chemistry, 30(5), 687-695 (1984-05-01)
A capillary gas-chromatographic method with nitrogen-phosphorus detection is used here to simultaneously determine 1,3-diaminopropane, putrescine, cadaverine, spermidine, spermine, isoputreanine , putreanine , and N-(3-aminopropyl)-N'-(2-carboxyethyl)-1,4- diaminobutane in urine. After acid hydrolysis the compounds are isolated by adsorption onto silica gel and...

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