137448

Sigma-Aldrich

2-Methyl-2-oxazoline

98%

Empirical Formula (Hill Notation):
C4H7NO
CAS Number:
Molecular Weight:
85.10
Beilstein/REAXYS Number:
104227
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

refractive index

n20/D 1.434 (lit.)

bp

109.5-110.5 °C (lit.)

density

1.005 g/mL at 25 °C (lit.)

SMILES string

CC1=NCCO1

InChI

1S/C4H7NO/c1-4-5-2-3-6-4/h2-3H2,1H3

InChI key

GUXJXWKCUUWCLX-UHFFFAOYSA-N

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General description

2-Methyl-2-oxazoline undergoes polymerization with 2-butyl-2-oxazoline to form poly(2-oxazoline) block copolymer. It undergoes cationic ring-opening polymerization with 2-(dec-9-enyl)-2-oxazoline to yield copoly(2-oxazoline)s.

Application

2-Methyl-2-oxazoline was used in cationic polymerization of a series of linear 2-alkyl-2-oxazolines under microwave irradiation.

Packaging

100 g in glass bottle

Pictograms

Flame

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 1993BF 3 / PGII

WGK Germany

WGK 3

Flash Point(F)

68.0 °F - closed cup

Flash Point(C)

20 °C - closed cup

Certificate of Analysis

Certificate of Origin

Jing Tong et al.
Molecular pharmaceutics, 10(1), 360-377 (2012-11-21)
Superoxide dismutase 1 (SOD1) efficiently catalyzes dismutation of superoxide, but its poor delivery to the target sites in the body, such as brain, hinders its use as a therapeutic agent for superoxide-associated disorders. Here to enhance the delivery of SOD1...
Ke Mao et al.
Talanta, 168, 230-239 (2017-04-11)
In this work, a one-step coating procedure by a simple annealing protocol of poly (2-methyl-2-oxazoline)-random-glycidyl methacrylate (PMOXA-r-GMA) copolymer was used to yield covalent and cross-linked PMOXA-based antifouling coating on a fused-silica capillary inner surface, which was used to determine the...
Laetitia Korchia et al.
Soft matter, 13(25), 4507-4519 (2017-06-07)
A series of amphiphilic photo-responsive heterografted copolymers have been successfully synthesized. The random copolymers were composed of a methacrylate backbone, with various compositions of hydrophilic oligomeric 2-methyl-2-oxazoline side chains (OMOx) and hydrophobic long alkyl chains terminated by a coumarin moiety...
Ondrej Sedlacek et al.
Journal of controlled release : official journal of the Controlled Release Society, 326, 53-62 (2020-06-23)
Poly(2-oxazoline)s represent an emerging class of polymers with increasing potential in biomedical sciences. To date, most of the work on poly(2-oxazoline)-drug conjugates focused on poly(2-ethyl-2-oxazoline) (PEtOx), a biocompatible water-soluble polymer with biological properties similar to polyethylene glycol. However, the more...
Denial Mahata et al.
Scientific reports, 7, 46412-46412 (2017-04-13)
Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with...

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