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137561

Sigma-Aldrich

3-Methyl-1-pentyn-3-ol

98%

Synonym(s):
Ethyl ethynyl methyl carbinol, Meparfynol
Linear Formula:
CH≡CC(OH)(CH3)CH2CH3
CAS Number:
Molecular Weight:
98.14
Beilstein:
969340
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

vapor density

3 (vs air)

vapor pressure

6.5 mmHg ( 20 °C)

assay

98%

form

liquid

refractive index

n20/D 1.431 (lit.)

bp

121-122 °C (lit.)

solubility

Cellosolve: miscible
Stoddard solvent: miscible
acetone: miscible
benzene: miscible
carbon tetrachloride: miscible
cyclohexanone: miscible
diethyl ether: soluble
diethylene glycol: miscible
ethanolamine: miscible
ethyl acetate: miscible
kerosene: miscible
mineral spirits: miscible
neatsfoot oil: miscible
petroleum ether: miscible
soybean oil: miscible

density

0.866 g/mL at 25 °C (lit.)

SMILES string

CCC(C)(O)C#C

InChI

1S/C6H10O/c1-4-6(3,7)5-2/h1,7H,5H2,2-3H3

InChI key

QXLPXWSKPNOQLE-UHFFFAOYSA-N

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General description

3-Methyl-1-pentyn-3-ol acts as initiator during the synthesis of propargyl-terminated polylactide by bulk ring-opening polymerization.

Application

3-Methyl-1-pentyn-3-ol is propargyl alcohol that can be used as:
  • A reactant to synthesize α-methylene cyclic carbonates by reacting with carbon dioxide.
  • A reactant in the synthesis of 2,6,9-trisubstituted purine based CDK inhibitors.
  • An initiator in the synthesis of polylactide bearing terminal propargyl group via ring-opening polymerization of L-lactide.

Packaging

100 mL in glass bottle

Biochem/physiol Actions

3-Methyl-1-pentyn-3-ol is a sedative and induces hepatic P4503A in mouse.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

82.4 °F - closed cup

Flash Point(C)

28 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

H Teräväinen et al.
Journal of neurology, neurosurgery, and psychiatry, 49(2), 198-199 (1986-02-01)
Six patients with essential tremor tested in the therapeutic effectiveness of a 6-carbon alcohol, methylpentynol, 200 mg/day, against placebo in a randomised double-blind clinical cross-over trial. The effect of methylpentynol on postural tremor amplitude was not different from that of
Preparation of propargyl-terminated polylactide by the bulk ring-opening polymerization.
Liu X, et al.
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 46(10), 937-942 (2009)
Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2, 6, 9-trisubstituted purine libraries. Part 3
Brun V, et al.
Tetrahedron Letters, 42(46), 8169-8171 (2001)
M I Walash et al.
Journal - Association of Official Analytical Chemists, 68(6), 1209-1212 (1985-11-01)
Titrimetric and spectrophotometric titration methods are described for the quantitative determination of acetylenic hypnotics ethchlorvynol, ethinamate, and meparfynol carbamate as pure substances and in dosage forms. The methods involve the use of different brominating agents. A known excess of the
Yanlong Gu et al.
The Journal of organic chemistry, 69(2), 391-394 (2004-01-17)
Reactions of propargylic alcohols with CO(2) in a [BMIm][PhSO(3)]/CuCl catalytic system to produce the corresponding alpha-methylene cyclic carbonates were conducted with high yields. Mild reaction conditions, enhanced rates, improved yields, and recyclable ionic liquid catalyst systems are the remarkable features

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