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139122

Sigma-Aldrich

Isobutyryl chloride

98%

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Linear Formula:
(CH3)2CHCOCl
CAS Number:
Molecular Weight:
106.55
Beilstein:
605393
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

vapor pressure

0.07 mmHg ( 20 °C)

Quality Level

Assay

98%

form

liquid

refractive index

n20/D 1.407 (lit.)

bp

91-93 °C (lit.)

mp

−90 °C (lit.)

density

1.017 g/mL at 25 °C (lit.)

SMILES string

CC(C)C(Cl)=O

InChI

1S/C4H7ClO/c1-3(2)4(5)6/h3H,1-2H3

InChI key

DGMOBVGABMBZSB-UHFFFAOYSA-N

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This Item
120847112208103918
Isobutyryl chloride 98%

Sigma-Aldrich

139122

Isobutyryl chloride

form

liquid

form

-

form

solid

form

-

refractive index

n20/D 1.407 (lit.)

refractive index

n20/D 1.536 (lit.)

refractive index

-

refractive index

n20/D 1.572 (lit.)

bp

91-93 °C (lit.)

bp

90-92 °C/15 mmHg (lit.)

bp

202-205 °C/105 mmHg (lit.)

bp

238 °C (lit.)

mp

−90 °C (lit.)

mp

4 °C (lit.)

mp

71-74 °C (lit.)

mp

−4-−3 °C (lit.)

density

1.017 g/mL at 25 °C (lit.)

density

1.328 g/mL at 25 °C (lit.)

density

-

density

1.382 g/mL at 25 °C (lit.)

General description

Isobutyryl chloride reacts with guanine to yield N(2)-isobutyrylguanine.

Application

Isobutyryl chloride was used in the synthesis of fully isobutyramide terminated hyperbranched polyethylenimines. It was used in the separation and identification of shikonin and its ester derivatives in the root epidermis of Echium italicum L. It was employed as versatile acylating agent for the ketimine derivatives of α-amino esters, nucleosides and pyrroles.
Versatile acylating agent for the ketimine derivatives of α-amino esters, nucleosides, and pyrroles.

Pictograms

FlameCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Flam. Liq. 2 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

46.4 °F - closed cup

Flash Point(C)

8 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 8

1 of 8

Lijing Yang et al.
Magnetic resonance in chemistry : MRC, 51(1), 60-64 (2012-11-21)
N(2)-isobutyrylguanine was prepared by treatment of guanine with isobutyryl chloride. Two tautomers, 1,7-dihydro-2-(isobutyroyl)amino-6H-purin-6-one and 1,9-dihydro-2-(isobutyroyl)amino-6H-purin-6-one, were identified in almost 1:1 ratio in dichloromethane-dimethyl sulfoxide (1:1 v/v) by NMR spectroscopy. By using the selective-inversion experiments, enthalpy, entropy, and free energy for activation
Heteroatom Chem., 4, 39-39 (1993)
Bioorganic & Medicinal Chemistry Letters, 3, 1207-1207 (1993)
Alen Albreht et al.
Journal of chromatography. A, 1216(15), 3156-3162 (2009-02-24)
Nine shikonin pigments: shikonin (S), acetylshikonin (AS), propionylshikonin (PS), isobutyrylshikonin (IBS), tiglylshikonin (TS), 3,3-dimethylacrylshikonin (DAS), angelylshikonin (ANS), 2-methyl-n-butyrylshikonin (MBS) and isovalerylshikonin (IVS) were identified in the root epidermis of Echium italicum L. for the first time. A new thin-layer chromatographic
Mathilde Ménard et al.
Biochimica et biophysica acta. General subjects, 1863(2), 332-341 (2018-11-06)
Human serum albumin (HSA) nanoparticles emerge as promising carriers for drug delivery. Among challenges, one important issue is the design of HSA nanoparticles with a low mean size of ca. 50 nm and having a high drug payload. The original strategy

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