139521

Sigma-Aldrich

2-(2-Chloroethyl)-1-methylpyrrolidine hydrochloride

99%

Empirical Formula (Hill Notation):
C7H14ClN · HCl
CAS Number:
Molecular Weight:
184.11
Beilstein/REAXYS Number:
6148386
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

mp

98-102 °C (lit.)

SMILES string

ClH.CN1CCCC1CCCl

InChI

1S/C7H14ClN.ClH/c1-9-6-2-3-7(9)4-5-8;/h7H,2-6H2,1H3;1H

InChI key

KCQMALZNENFGKK-UHFFFAOYSA-N

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Application

2-(2-Chloroethyl)-1-methylpyrrolidine hydrochloride was used in the synthesis of N-2-(1-methylpyrrolidin-2-yl)ethyl-N-(2-iodo-4,5-dimethoxyphenyl) amide. It was used as reagent during the synthesis of 1-methyl-2-2-2-(2-phenylethyl)phenoxyethylpyrrolidine hydrochlochloride.

Packaging

5, 25 g in glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

N Tanaka et al.
Chemical & pharmaceutical bulletin, 48(2), 245-255 (2000-03-08)
A series of [2-(omega-phenylalkyl)phenoxy]alkylamines was synthesized and their receptor binding affinity was examined in vitro. These compounds showed an affinity for serotonin-2 (5-HT2) and dopamine-2 (D2) receptors. [2-(2-phenylethyl)phenoxy]alkylamine derivatives with a pyrrolidine or piperidine moiety in the structure showed higher...
Shejin Zhu et al.
Bioorganic & medicinal chemistry, 14(9), 3131-3143 (2006-01-18)
6-Substituted 8,9-dimethoxy-2,3-methylenedioxy-6H-dibenzo[c,h][2,6]naphthyridin-5-ones were synthesized and evaluated for topoisomerase I-targeting activity and cytotoxicity. Several of these reversed lactam analogues of ARC-111 exhibited exceptional cytotoxicity with IC50 values ranging from 0.5 to 3.0 nM. In contrast to topotecan, no resistance was observed...

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