150355

Sigma-Aldrich

4-tert-Butylbenzoic acid

99%

Linear Formula:
(CH3)3CC6H4CO2H
CAS Number:
Molecular Weight:
178.23
Beilstein/REAXYS Number:
607545
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

mp

162-165 °C (lit.)

SMILES string

CC(C)(C)c1ccc(cc1)C(O)=O

InChI

1S/C11H14O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h4-7H,1-3H3,(H,12,13)

InChI key

KDVYCTOWXSLNNI-UHFFFAOYSA-N

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General description

4-tert-Butylbenzoic acid was determined in water samples by means of liquid chromatography-electrospray ionisation mass spectrometry (LC-ESI-MS).

Application

4-tert-Butylbenzoic acid was used as a potent yeast sirtuin (Sir2p) inhibitor.

Packaging

500 g in poly bottle
2 kg in poly drum

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

316.4 °F - closed cup

Flash Point(C)

158 °C - closed cup

Patrycja Makoś et al.
Journal of chromatography. A, 1517, 26-34 (2017-09-01)
The paper presents a new method for the determination of 15 carboxylic acids in samples of postoxidative effluents from the production of petroleum bitumens using ion-pair dispersive liquid-liquid microextraction and gas chromatography coupled to mass spectrometry with injection port derivatization....
Yi-Pei Chen et al.
Bioorganic & medicinal chemistry letters, 24(1), 349-352 (2013-11-26)
Employing a genetically modified yeast strain as a screening tool, 4-dimethylaminobenzoic acid (5) was isolated from the marine sediment-derived Streptomyces sp. CP27-53 as a weak yeast sirtuin (Sir2p) inhibitor. Using this compound as a scaffold, a series of disubstituted benzene...
Inhibition of hepatic gluconeogenesis and lipogenesis by benzoic acid, p-tert.-butylbenzoic acid, and a structurally related hypolipidemic agent SC-33459.
S A McCune et al.
Archives of biochemistry and biophysics, 214(1), 124-133 (1982-03-01)
I Anundi et al.
Chemico-biological interactions, 50(3), 277-288 (1984-08-01)
Isolated hepatocytes incubated with selenite (30-100 microM) exhibited changes in the glutathione redox system as shown by an increase in O2 consumption, oxidation of glutathione and loss of NADPH. Selenite (50 microM) raised O2 consumption within the 1 h and...
Adeline Martin et al.
Carbohydrate polymers, 93(2), 718-730 (2013-03-19)
The aim of this work was to develop the formation of multilayered coating incorporating a cyclodextrin polyelectrolyte onto a non-woven polyethylene terephthalate (PET) textile support in order to obtain reservoir and sustained release properties towards bioactive molecules. We optimized the...

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