151270

Sigma-Aldrich

1-(2-Pyridyl)piperazine

98%

Synonym(s):
2-Piperazinopyridine
Empirical Formula (Hill Notation):
C9H13N3
CAS Number:
Molecular Weight:
163.22
Beilstein/REAXYS Number:
140423
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

refractive index

n20/D 1.595 (lit.)

bp

120-122 °C/2 mmHg (lit.)

density

1.072 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ccccn2

InChI

1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2

InChI key

GZRKXKUVVPSREJ-UHFFFAOYSA-N

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Application

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

Packaging

5, 25 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

hazcat

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

10 - Combustible liquids

WGK Germany

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
Journal of Chromatography A, 212(1), 93-104 (1981)
Harvey Wong et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1387-1392 (2007-05-15)
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-OH-buspirone in rats...
Tengxuan Tang et al.
Journal of fluorescence, 29(2), 445-450 (2019-02-03)
A new fluorescent sensor was designed and synthesized from 5-nitro-1,2-dihydroacenaphthylene, n-butyl amine and 1-(2-pyridyl)piperazine. In DMF/H2O (3:1, v/v), the sensor showed excellent selectivity and sensitivity to Fe3+ with fast fluorescence enhancement and good anti-interference ability. The maximal fluorescence intensity was...
P Giral et al.
European journal of pharmacology, 134(1), 113-116 (1987-01-28)
We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha-adrenergic function. Both effects were...

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