15140

Sigma-Aldrich

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride

≥97.0% (AT)

Synonym(s):
BOP-Cl, Phosphoric acid bis(2-oxooxazolidide) chloride
Empirical Formula (Hill Notation):
C6H8ClN2O5P
CAS Number:
Molecular Weight:
254.56
Beilstein/REAXYS Number:
3654596
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

≥97.0% (AT)

mp

191 °C (dec.) (lit.)

SMILES string

ClP(=O)(N1CCOC1=O)N2CCOC2=O

InChI

1S/C6H8ClN2O5P/c7-15(12,8-1-3-13-5(8)10)9-2-4-14-6(9)11/h1-4H2

InChI key

KLDLRDSRCMJKGM-UHFFFAOYSA-N

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Application

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride was used in the preparation of hexadepsipeptide.

Packaging

5, 25 g in glass bottle

Other Notes

Reagent for activating the carboxylic group, synthesis of amides ; Esters ; Peptides

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

C

Risk Statement

34

Safety Statement

26-36/37/39-45

RIDADR

UN 3261 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
S. Danishefsky et al
Tetrahedron Letters, 25, 4203-4203 (1984)
Zhao Yanbin et al.
Biochemical and biophysical research communications, 516(1), 102-111 (2019-06-16)
Here, we firstly examined the proliferation and invasion capacities of different osteosarcoma (OS) cell lines, and analyzed the profiling of the differentially expressed circular RNAs(circRNAs). Then, we identified a novel circRNA(circ_101356/circ_0004846, we named circSAMD4 in the present study) and found...
J. Cabre et al.
Synthesis, 413-413 (1984)
H T Le et al.
Bioorganic & medicinal chemistry, 4(12), 2201-2209 (1996-12-01)
BOP-Cl was found to be an efficient coupling reagent for the introduction of thiopeptide bonds on imino acid residues (Pro, Sar). Boc-amino monothioacids were coupled at moderate temperature (0 degree C-RT) with fair yields and with retained optical purity. The...
Liza L Ramenzoni et al.
Materials (Basel, Switzerland), 12(9) (2019-05-01)
Improving soft tissue attachment to implant abutments is a crucial factor for enduring health and maintenance of soft peri-implant tissue health. In this in vitro study we aimed to compare the biocompatibility of three different abutment surfaces: titanium, zirconia and...

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