161896

Sigma-Aldrich

3,4-Dibenzyloxyphenethylamine hydrochloride

98%

Linear Formula:
(C6H5CH2O)2C6H3CH2CH2NH2 · HCl
CAS Number:
Molecular Weight:
369.88
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

assay

98%

mp

131-133 °C (lit.)

SMILES string

Cl.NCCc1ccc(OCc2ccccc2)c(OCc3ccccc3)c1

InChI

1S/C22H23NO2.ClH/c23-14-13-18-11-12-21(24-16-19-7-3-1-4-8-19)22(15-18)25-17-20-9-5-2-6-10-20;/h1-12,15H,13-14,16-17,23H2;1H

InChI key

KXIZXPRLNNDQKS-UHFFFAOYSA-N

Related Categories

Application

3,4-Dibenzyloxyphenethylamine hydrochloride was used in the synthesis of tetrahydroisoquinoline derivatives containing 4(hexylureido)benzenesulfonamide, human β3 adrenergic receptor agonist. It was used as reagent in synthesis of the prodrugs of dopamine.

Packaging

5 g in glass bottle

Signal Word

Danger

Target Organs

Respiratory system

RIDADR

UN 3077 9 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Lauri Peura et al.
Pharmaceutical research, 30(10), 2523-2537 (2013-10-19)
Drug delivery to the brain is impeded by the blood-brain barrier (BBB). Here, we attempted to enhance the brain uptake of cationic dopamine by utilizing the large amino acid transporter 1 (LAT1) at the BBB by prodrug approach. Three amino...
E R Parmee et al.
Bioorganic & medicinal chemistry letters, 10(20), 2283-2286 (2000-10-31)
Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human beta3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the beta3 AR. Naphthyloxy compound 18 (beta3 EC50 = 78 nM) did not activate the...

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