162531

Sigma-Aldrich

3-Fluorobenzoyl chloride

98%

Linear Formula:
FC6H4COCl
CAS Number:
Molecular Weight:
158.56
Beilstein/REAXYS Number:
636610
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

98%

refractive index

n20/D 1.529 (lit.)

bp

189 °C (lit.)

mp

−30 °C (lit.)

density

1.304 g/mL at 25 °C (lit.)

SMILES string

Fc1cccc(c1)C(Cl)=O

InChI

1S/C7H4ClFO/c8-7(10)5-2-1-3-6(9)4-5/h1-4H

Inchi Key

SYVNVEGIRVXRQH-UHFFFAOYSA-N

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Application

3-Fluorobenzoyl chloride was used in synthesis of 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinyl-benzamide by radiosynthesis. It was also used as reagent in one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides. It was used in three phase hollow fiber liquid-phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.

Packaging

5, 25 g in glass bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3265 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

179.6 °F - closed cup

Flash Point(C)

82 °C - closed cup

D Le Bars et al.
Nuclear medicine and biology, 25(4), 343-350 (1998-06-25)
No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controlled radiosynthesis. Baseline separation of p-[18F]MPPF from the...
An efficient one-pot synthesis of N-(1, 3-diphenyl-1H-pyrazol-5-yl) amides.
Su W-N, et al.
Journal of Heterocyclic Chemistry, 47(4), 831-837 (2010)
Gazala Mohamed Ben-Hander et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 941, 123-130 (2013-11-10)
A three phase hollow fiber liquid-phase microextraction with in situ derivatization (in situ HF-LPME) followed by high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed for the trace determination of metformin hydrochloride (MH) in biological fluids. A new derivatization agent pentafluorobenzoyl...
Dima A Sabbah et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 15(4), 417-429 (2018-09-13)
Phosphoinositide 3-kinase α (PI3Kα) has emerged as a promising target for anticancer drug design. Target compounds were designed to investigate the effect of the p-OCH3 motifs on ligand/PI3Kα complex interaction and antiproliferative activity. Synthesis of the proposed compounds, biological examination...

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