17356

Sigma-Aldrich

3-(Boc-amino)propyl bromide

≥96.0% (GC)

Synonym(s):
tert-Butyl N-(3-bromopropyl)carbamate
Linear Formula:
Br(CH2)3NHCO2C(CH3)3
CAS Number:
Molecular Weight:
238.12
Beilstein/REAXYS Number:
4176344
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

≥96.0% (GC)

reaction suitability

reagent type: cross-linking reagent
reagent type: spacer

mp

37-39 °C

storage temp.

2-8°C

SMILES string

CC(C)(C)OC(=O)NCCCBr

InChI

1S/C8H16BrNO2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6H2,1-3H3,(H,10,11)

InChI key

IOKGWQZQCNXXLD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

3-(Boc-amino)propyl bromide can be used as an alkylating reagent for the synthesis of:
  • Benzydamine analogs to be used as activators for soluble guanylate cyclase.
  • N-substituted chromenotriazolopyrimidine, human murine double minute 2 (MDM2) inhibitor.
  • Protected amines from piperidine derivatives to be further used for synthesis of sulfonamide series.

It can also be used for the post-polymerization quaternization of polymers to synthesize functional cationic polymers and antimicrobial agents.

Packaging

2.5 g in poly bottle
500 mg in poly bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.
Beck HP, et al.
Bioorganic & Medicinal Chemistry Letters, 21(9), 2752-2755 (2011)
Design, syntheses and evaluation of hemocompatible pegylated-antimicrobial polymers with well-controlled molecular structures.
Venkataraman S, et al.
Biomaterials, 31(7), 1751-1756 (2010)
Identification of selective 8-(piperidin-4-yloxy) quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis.
Procopiou PA, et al.
Bioorganic & Medicinal Chemistry Letters, 27(21), 4914-4919 (2017)
Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.
Selwood DL, et al.
Journal of medicinal chemistry, 44(1), 78-93 (2001)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.