125 °C (lit.)
86-89 °C (lit.)
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Aquatic Chronic 2 - Eye Dam. 1 - Flam. Sol. 1 - Skin Corr. 1A
4.1B - Flammable solid hazardous materials
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
It is soluble in organic solvents such as chloroform, toluene, tetrahydrofuran (THF), and dichloromethane. It reacts with water.
This product is a versatile protecting reagent for amines, amides, and especially alcohols.
When this compound was initially used as a silylation agent, it was found by E. J. Corey (J. Am. Chem. Soc. 1972, 94, 6192) to react very slowly and to give unsatisfactory yields with alcohols. Even forcing silylation techniques (excess silyl chloride, dry pyridine, elevated temperatures) were not successful. The use of 2.5 eq. imidazole as catalyst with 1.2 eq. of tert-butyldimethylsilyl chloride and dimethylformamide as solvent proved to be effective, and resulted in the mild conversion of various alcohols to tert-butyldimethylsilyl ethers in high yield.
Since this product is readily hydrolyzed, we do package this product under nitrogen atmosphere.
This silylating agent can be used to determine conformation of cholesterol derivatives.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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