191906

Sigma-Aldrich

Hydroxypropyl cellulose

average Mw ~1,000,000, powder, 20 mesh particle size (99% through)

CAS Number:
MDL number:
NACRES:
NA.23
Pricing and availability is not currently available.

Quality Level

form

powder

autoignition temp.

752 °F

mol wt

average Mw ~1,000,000

biological oxygen demand (BOD)

14,000 ppm

impurities

<5 wt. %

particle size

20 mesh (99% through)

pH range

5.0 - 8.5

interfacial tension mineral oil

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosity

1,275-3,500 cP, 1 wt. % in H2O(25 °C, Brookfield, spindle #3) (30 rpm)(lit.)

solubility

H2O: insoluble (above 45 °C)
polar organic solvents: soluble

density

0.5 g/mL at 25 °C (lit.)

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dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

R Logan et al.
Drug development and industrial pharmacy, 38(11), 1394-1404 (2012-03-23)
Impeller speed was varied from 300 to 1500 rpm during the wet high shear granulation of a placebo formulation using a new vertical shaft PharmaMATRIX-1 granulator. The resulting granules were extensively analysed for differences caused by the varying impeller speed...
Noorullah Naqvi Mohammed et al.
AAPS PharmSciTech, 13(4), 1158-1169 (2012-09-11)
The objective of this research work was to evaluate Klucel™ hydroxypropylcellulose (HPC) EF and ELF polymers, for solubility enhancement as well as to address some of the disadvantages associated with solid dispersions. Ketoprofen (KPR), a Biopharmaceutics Classification System class II...
Ashish Sarode et al.
AAPS PharmSciTech, 14(1), 151-159 (2012-12-20)
Hydroxypropylcellulose (HPC)-SL and -SSL, low-viscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. The utility of HPC polymers was assessed for both dissolution enhancement and sustained release of pharmaceutical drugs using various processing techniques. The BCS class II drugs carbamazepine (CBZ), hydrochlorthiazide...
Kassibla E Dempah et al.
AAPS PharmSciTech, 14(1), 19-28 (2012-11-28)
Solid-state NMR spectroscopy (SSNMR), coupled with powder X-ray diffraction (PXRD), was used to identify the physical forms of gabapentin in samples prepared by recrystallization, spray drying, dehydration, and milling. Four different crystalline forms of gabapentin were observed: form I, a...
Alexandre Monteiro et al.
Drug development and industrial pharmacy, 39(2), 266-283 (2012-04-17)
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via...

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