MilliporeSigma
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193984

Sigma-Aldrich

1-Methylindole

≥97%

Synonym(s):
NSC 212534
Empirical Formula (Hill Notation):
C9H9N
CAS Number:
Molecular Weight:
131.17
Beilstein:
111026
EC Number:
MDL number:
PubChem Substance ID:

assay

≥97%

form

liquid

refractive index

n20/D 1.606 (lit.)

bp

133 °C/26 mmHg (lit.)

density

1.051 g/mL at 20 °C (lit.)

SMILES string

Cn1ccc2ccccc12

InChI

1S/C9H9N/c1-10-7-6-8-4-2-3-5-9(8)10/h2-7H,1H3

InChI key

BLRHMMGNCXNXJL-UHFFFAOYSA-N

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General description

1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.

Application

1-Methylindole was used in the determination of association constant for the electron-donor-acceptor complexes of 1-methylindole with 1-(2,4,6-trinitrophenyl) propan-2-one.
Reactant for preparation of:
  • Pharmaceutically active 2-oxo-1-pyrrolidine analogues
  • Non-receptor tyrosine kinase (Src kinase) inhibitors
  • PET agents for imaging of protein kinase C (PKC)
  • Ynediones as highly reactive Michael systems
  • Anticancer agents
  • Polycyclic derivatives of indoles
  • PET agents for imaging of glycogen synthase kinase-3 (GSK-3)
  • Anti-prion disease agents
  • Bisindole derivatives with antihyperlipidemic activity
  • PET cancer imaging agents

Packaging

5, 25, 100 g

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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