194751

Sigma-Aldrich

N-tert-Butylhydroxylamine hydrochloride

≥98%

Linear Formula:
(CH3)3CNHOH · HCl
CAS Number:
Molecular Weight:
125.60
Beilstein/REAXYS Number:
3546053
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

≥98%

mp

183-185 °C (lit.)

SMILES string

Cl.CC(C)(C)NO

InChI

1S/C4H11NO.ClH/c1-4(2,3)5-6;/h5-6H,1-3H3;1H

InChI key

DCSATTBHEMKGIP-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

N-tert-Butylhydroxylamine hydrochloride was used in spin trapping of short-lived radicals. It was also used in the synthesis of α-ketoamides and 3-spirocyclopropanated 2-azetidinones.

Packaging

1 g in glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

A New Three-Component Cascade Reaction to Yield 3-Spirocyclopropanated?-Lactams.
Zanobini A, et al.
European Journal of Organic Chemistry, 2006(5), 1251-1255 (2006)
On the anti-aging activities of aminoguanidine and N-t-butylhydroxylamine.
A R Hipkiss
Mechanisms of ageing and development, 122(2), 169-171 (2001-02-13)
Jin Hyup Lee et al.
Carcinogenesis, 25(8), 1435-1442 (2004-03-16)
Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. Therefore, compounds that scavenge ROS may confer radioprotective effects. Recently, it has been shown that the decomposition product of the...
Ludmila A Voloboueva et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21(14), 4077-4086 (2007-07-28)
Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in the elderly in developed countries. AMD patients have elevated levels of iron within the retinal pigment epithelia (RPE), which may lead to oxidative damage to mitochondria, disruption...
C Lagercrantz
Free radical research communications, 14(5-6), 395-407 (1991-01-01)
Spin trapping of short-lived R. radicals is done by use of N-tert-butylhydroxylamine (1) and H2O2. The hydroxylamine is oxidized to the radical t-BuN(O)H (2) which is converted into the spin trap 2-methyl-2-nitrosopropane (3). Simultaneously, hydroxyl radicals .OH are formed from...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.