Tobias Tengel et al.
Organic & biomolecular chemistry, 2(5), 725-731 (2004-02-27)
Identification of compounds from chemical libraries that bind to macromolecules by use of NMR spectroscopy has gained increasing importance during recent years. A simple methodology based on (19)F NMR spectroscopy for the screening of ligands that bind to proteins, which...
B Chandrakantha et al.
European journal of medicinal chemistry, 45(3), 1206-1210 (2009-12-17)
In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds...
R D Farrant et al.
Journal of pharmaceutical and biomedical analysis, 13(8), 971-977 (1995-07-01)
Many drugs containing carboxylic acid functional groups are metabolised in vivo to ester glucuronides (1-O-acyl-beta-D-glucopyranuronates) and, of these, a number show a propensity to undergo internal isomerisation via a transacylation process, causing the carboxylic acid moiety to migrate successively to...
Studies on the metabolism of fluorinated xenobiotics in the rat using 19F-NMR and 1H-NMR spectroscopy.
F Y Ghauri et al.
Journal of pharmaceutical and biomedical analysis, 8(8-12), 939-944 (1990-01-01)