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202398

Sigma-Aldrich

Poly(ethylene glycol)

greener alternative

average Mn 400, hydroxyl

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Synonym(s):
Polyethylene glycol, PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
12352104
PubChem Substance ID:
NACRES:
NA.23

form

viscous liquid

Quality Level

mol wt

Mn 380-420
average Mn 400

greener alternative product characteristics

Safer Solvents and Auxiliaries
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sustainability

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refractive index

n20/D 1.466

pH

4.5-7.5

viscosity

7.3 cSt(210 °F)(lit.)

mp

4-8 °C (lit.)

density

1.128 g/mL

Ω-end

hydroxyl

α-end

hydroxyl

greener alternative category

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are non-toxic, FDA-approved, generally non-immunogenic, and frequently used in many biomedical applications including bioconjugation, drug delivery, surface functionalization, and tissue engineering. In drug delivery, PEGs can be used as linkers for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery.

Application

Poly(ethylene glycol) (PEG) has been used as a coating agent for the synthesis and in vitro safety assessment of magnetic bacterial cellulose (MBC) pellicles, performed on porcine aortic smooth muscle cells (PAOSMC). PEG provides a compatible surface for cell culture, since uncoated iron oxide NPs are considered cytotoxic to cells. It has also been used as a plasticizer in investigating the effectiveness of polyvinylpyrrolidone microneedles for transdermal delivery of functional collagen using porcine skin, adult human skin analog and human foreskin. Microneedles obtained, were reportedly characterized by various analytical and bio-analytical techniques.
Used in conjunction with carbon black to form a conductive composite. Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.

Legal Information

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis and in vitro safety assessment of magnetic bacterial cellulose with porcine aortic smooth muscle cells
Pastrana FH, et al.
Journal of Biomedical Materials Research Part A, 104(11), 2801-2809 (2016)
Transdermal delivery of functional collagen via polyvinylpyrrolidone microneedles
Sun W, et al.
Annals of Biomedical Engineering, 43(12), 2978-2990 (2015)
Changxin Wan et al.
Cancer research, 81(1), 158-173 (2020-11-08)
Immune therapies have had limited efficacy in high-grade serous ovarian cancer (HGSC), as the cellular targets and mechanism(s) of action of these agents in HGSC are unknown. Here we performed immune functional and single-cell RNA sequencing transcriptional profiling on novel
Akashi, M., Akagi, T.
Yuki Gosei Kaguku Kyokaishi, 65, 520-520 (2004)
Ruth Hernandez-Perez et al.
Physical review. E, 96(6-1), 062803-062803 (2018-01-20)
The evaporation of droplets can give rise to a wide range of interesting phenomena in which the dynamics of the evaporation are crucial. In this work, we find simple scaling laws for the evaporation dynamics of axisymmetric droplets pinned on

Related Content

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

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