211370

Sigma-Aldrich

Sulfamide

99%

Linear Formula:
(NH2)2SO2
CAS Number:
Molecular Weight:
96.11
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

mp

90-92 °C (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

density

1.611 g/mL at 25 °C (lit.)

SMILES string

NS(N)(=O)=O

InChI

1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4)

InChI key

NVBFHJWHLNUMCV-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA2(760)

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Application

Sulfamide was used in the synthesis of:
  • Schiff bases of the type ArCH=NSO2NH2
  • 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD)
  • sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.

Packaging

5, 25 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Bacterial cleavage of nitrogen to sulfone bonds in sulfamide and 1H-2, 1, 3-benzothiadiazin-4 (3H)-one 2, 2-dioxide: formation of 2-nitrobenzamide by Gordonia sp.
Rein U and Cook AM.
FEMS Microbiology Letters, 172(2), 107-113 (1999)
Anthony Bertucci et al.
Bioorganic & medicinal chemistry letters, 19(3), 650-653 (2009-01-06)
The inhibition of a coral carbonic anhydrase (CA, EC 4.2.1.1) has been investigated with a series of inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate. The full-length scleractinian coral Stylophora pistillata CA, STPCA...
Jean-Yves Winum et al.
Bioorganic & medicinal chemistry letters, 15(9), 2353-2358 (2005-04-20)
A small library of N-hydroxysulfamides was synthesized by an original approach in order to investigate whether this zinc-binding function is efficient for the design of inhibitors targeting the cytosolic (hCA I and II) and transmembrane, tumor-associated (hCA IX and XII)...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 19(4), 1155-1158 (2009-01-09)
The membrane-associated mouse isozyme of carbonic anhydrase XV (mCA XV), has been investigated for its interaction with anion inhibitors. mCA XV is an isoforms possessing a very particular inhibition profile by anions, dissimilar to that of all other mammalian CAs...
Anna Di Fiore et al.
Bioorganic & medicinal chemistry letters, 20(12), 3601-3605 (2010-05-18)
We investigated the inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms I-XV with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfamide and other simple or sugar sulfamides, a class of less investigated CA inhibitors (CAIs). The crystal structure of the adduct of hCA II with the boron-substituted...

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