219746

Sigma-Aldrich

DL-Homocysteic acid

97%

Synonym(s):
DL-2-Amino-4-sulfobutyric acid
Linear Formula:
HO3SCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
183.18
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

97%

mp

273 °C (dec.) (lit.)

solubility

water: soluble 50 mg/mL, clear to slightly hazy, colorless to yellow

SMILES string

NC(CCS(O)(=O)=O)C(O)=O

InChI

1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)

InChI key

VBOQYPQEPHKASR-UHFFFAOYSA-N

General description

Complexes of DL-homocysteic acid with Na+, Cu2+, Zn2+ and Ni2+ has been synthesized. DL-Homocysteic acid induces oxidative stress in brain of immature rats.

Packaging

5 g in glass bottle

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Hui-Zhen Jia et al.
Guang pu xue yu guang pu fen xi = Guang pu, 27(7), 1291-1294 (2007-10-20)
The complexes of DL-homocysteic acid (DLH) with Na+, Cu2+, Zn2+ and Ni2+ were synthesized and elemental analyses were used to detect the compositions of these complexes. FTIR spectroscopy was employed to study these coordination structures. The results indicated that all...
Glauber S F da Silva et al.
Frontiers in physiology, 8, 452-452 (2017-07-18)
Hydrogen Sulfide (H
Jaroslava Folbergrová et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(2), 123-130 (2012-12-15)
We have recently demonstrated the evidence of oxidative stress in brain of immature rats during seizures induced by DL-homocysteic acid (DL-HCA). The aim of the present study was to investigate the antioxidant defense mechanisms under these conditions. Seizures were induced...
Tohru Hasegawa et al.
PloS one, 5(1), e8593-e8593 (2010-01-26)
Alzheimer's disease (AD) is an age-associated progressive neurodegenerative disorder with dementia, the exact pathogenic mechanisms of which remain unknown. We previously reported that homocysteic acid (HA) may be one of the pathological biomarkers in the brain with AD and that...
Asya Makhro et al.
American journal of physiology. Cell physiology, 298(6), C1315-C1325 (2010-05-12)
N-methyl-d-aspartate (NMDA) receptors are ligand-gated nonselective cation channels mediating fast neuronal transmission and long-term potentiation in the central nervous system. These channels have a 10-fold higher permeability for Ca(2+) compared with Na(+) or K(+) and binding of the agonists (glutamate...

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