220590

Sigma-Aldrich

Sodium orthovanadate

Linear Formula:
Na3VO4
CAS Number:
Molecular Weight:
183.91
EC Number:
MDL number:

mp

850-866 °C (lit.)

SMILES string

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

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Application

Agent used in the study of diabetes.

Biochem/physiol Actions

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.

Certificate of Analysis

Certificate of Origin

A Valera et al.
The Journal of clinical investigation, 92(1), 4-11 (1993-07-01)
Oral administration of vanadate to diabetic streptozotocin-treated rats decreased the high blood glucose and D-3-hydroxybutyrate levels related to diabetes. The increase in the expression of the P-enolpyruvate carboxykinase (PEPCK) gene, the main regulatory enzyme of gluconeogenesis, was counteracted in the...

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