222402

Sigma-Aldrich

Methylguanidine hydrochloride

98%

Linear Formula:
CH3NHC(=NH)NH2·HCl
CAS Number:
Molecular Weight:
109.56
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

assay

98%

solubility

water: soluble 50 mg/mL, clear

SMILES string

Cl.CNC(N)=N

InChI

1S/C2H7N3.ClH/c1-5-2(3)4;/h1H3,(H4,3,4,5);1H

InChI key

VJQCNCOGZPSOQZ-UHFFFAOYSA-N

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Application

Methylguanidine hydrochloride can be used to prepare:
  • Biaryl derivatives as BACE1 inhibitors.
  • Modified xylose, which is used in the synthesis of biodegradable composite hydrogels.
  • Methylguanidinium borohydride ionic liquid, which is applicable as a hydrogen storage material.

Packaging

1, 5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Jared N Cumming et al.
Bioorganic & medicinal chemistry letters, 22(7), 2444-2449 (2012-03-07)
From an initial lead 1, a structure-based design approach led to identification of a novel, high-affinity iminohydantoin BACE1 inhibitor that lowers CNS-derived Aβ following oral administration to rats. Herein we report SAR development in the S3 and F' subsites of...
A non-covalent strategy for montmorillonite/xylose self-healing hydrogels
Qi X, et al.
Royal Society of Chemistry Advances, 5(51), 41006-41012 (2015)
Methylguanidinium borohydride: an ionic-liquid-based hydrogen-storage material
Doroodian A, et al.
Angewandte Chemie (International ed. in English), 49(10), 1871-1873 (2010)
Jovana Vušurović et al.
ChemistryOpen, 6(6), 739-750 (2017-12-12)
Interactions of ribonucleic acid (RNA) with guanidine and guanidine derivatives are important features in RNA-protein and RNA-drug binding. Here we have investigated noncovalently bound complexes of an 8-nucleotide RNA and six different ligands, all of which have a guanidinium moiety...
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor
Cumming JN, et al.
Bioorganic & Medicinal Chemistry Letters, 22(7), 2444-2449 (2012)

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