Jared N Cumming et al.
Bioorganic & medicinal chemistry letters, 22(7), 2444-2449 (2012-03-07)
From an initial lead 1, a structure-based design approach led to identification of a novel, high-affinity iminohydantoin BACE1 inhibitor that lowers CNS-derived Aβ following oral administration to rats. Herein we report SAR development in the S3 and F' subsites of...
A non-covalent strategy for montmorillonite/xylose self-healing hydrogels
Qi X, et al.
Royal Society of Chemistry Advances, 5(51), 41006-41012 (2015)
Methylguanidinium borohydride: an ionic-liquid-based hydrogen-storage material
Doroodian A, et al.
Angewandte Chemie (International ed. in English), 49(10), 1871-1873 (2010)
Jovana Vušurović et al.
ChemistryOpen, 6(6), 739-750 (2017-12-12)
Interactions of ribonucleic acid (RNA) with guanidine and guanidine derivatives are important features in RNA-protein and RNA-drug binding. Here we have investigated noncovalently bound complexes of an 8-nucleotide RNA and six different ligands, all of which have a guanidinium moiety...
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor
Cumming JN, et al.
Bioorganic & Medicinal Chemistry Letters, 22(7), 2444-2449 (2012)