222712

Sigma-Aldrich

2-Fluorocinnamic acid

98%

Linear Formula:
FC6H4CH=CHCO2H
CAS Number:
Molecular Weight:
166.15
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

98%

mp

178-180 °C (lit.)

SMILES string

OC(=O)\C=C\c1ccccc1F

InChI

1S/C9H7FO2/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6H,(H,11,12)/b6-5+

InChI key

IOUDZAFBPDDAMK-AATRIKPKSA-N

Application

2-Fluorocinnamic acid was used in the synthesis of acrylamide.

Packaging

5 g in glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Alexandre L'Heureux et al.
Bioorganic & medicinal chemistry letters, 15(2), 363-366 (2004-12-18)
Replacement of the morpholinyl moiety in (S,E)-N-[1-(3-morpholinophenyl)ethyl]-3-phenylacrylamide (1) with heteroaryl groups led to the identification of (S,E)-N-1-[3-(6-fluoropyridin-3-yl)phenyl]ethyl-3-(2-fluorophenyl)acrylamide (5) as a potent KCNQ2 potassium channel opener. Among this series of heteroaryl substituted acrylamides, (S,E)-N-1-[3-(1H-pyrazol-1-yl)phenyl]ethyl-3-(2-fluorophenyl)acrylamide (9) exhibits balanced potency and efficacy. The...

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