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222801

Sigma-Aldrich

4-Nitrobenzyl chloroformate

97%

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Synonym(s):
(4-Nitrophenyl)methyl carbonochloridate, (4-Nitrophenyl)methyl chloroformate, 4-Nitrobenzyloxycarbonyl chloride, p-Nitrobenzyloxycarbonyl chloride, p-nitrobenzyl chloroformate
Linear Formula:
ClCO2CH2C6H4NO2
CAS Number:
Molecular Weight:
215.59
Beilstein/REAXYS Number:
912446
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

97%

reaction suitability

reaction type: Carbonylations

mp

32-34 °C (lit.)

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(COC(Cl)=O)cc1

InChI

1S/C8H6ClNO4/c9-8(11)14-5-6-1-3-7(4-2-6)10(12)13/h1-4H,5H2

InChI key

MHSGOABISYIYKP-UHFFFAOYSA-N

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1 of 4

This Item
420069112208N9876
vibrant-m

222801

4-Nitrobenzyl chloroformate

vibrant-m

112208

4-Nitrobenzoyl chloride

vibrant-m

N9876

4-Nitrophenyl butyrate

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

32-34 °C (lit.)

mp

125 °C (dec.) (lit.)

mp

71-74 °C (lit.)

mp

-

reaction suitability

reaction type: Carbonylations

reaction suitability

-

reaction suitability

-

reaction suitability

-

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

-

application(s)

-

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible, corrosive hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Eun Hyang Jang et al.
International journal of pharmaceutics, 580, 119237-119237 (2020-03-24)
Hypoxia is a characteristic feature of various ischemic diseases, including cancer. This study describes the development of glycol chitosan nanoparticles, hydrophobically modified with 4-nitrobenzyl chloroformate and folic acid (FA), that can specifically release drugs under hypoxic conditions. This hypoxia-responsive glycol

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