α-Hydroxyhippuric acid


(Benzoylamino)hydroxyacetic acid
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:




211 °C (dec.) (lit.)

SMILES string




InChI key


Related Categories

General description

α-Hydroxyhippuric acid, nonpeptidic substrate, forms complex with peptidyl-α-hydroxyglycine α-amidating lyase catalytic core.


α-Hydroxyhippuric acid was used in the synthesis of benzamide by the enzyme-catalyzed dealkylation reaction.


5, 25 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 223875.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

A G Katopodis et al.
Biochemistry, 29(26), 6115-6120 (1990-07-03)
We report here the isolation of a novel enzyme from bovine neurointermediate pituitary which catalyzes the conversion of alpha-hydroxybenzoylglycine to benzamide. This enzyme, termed HGAD (alpha-hydroxyglycine amidating dealkylase), is a soluble protein with an apparent molecular mass of 45 kDa...
Xiaoning Wang et al.
Journal of proteome research, 11(7), 3838-3847 (2012-05-26)
Cirrhosis is a common and terminal outcome of many chronic liver conditions. A urinary metabonomic study using gas chromatography-mass spectrometry (GC-MS) and ultra performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOFMS) was carried out to elucidate the pathophysiological basis of posthepatitis...
Eduardo E Chufán et al.
Structure (London, England : 1993), 17(7), 965-973 (2009-07-17)
Many neuropeptides and peptide hormones require amidation of their carboxy terminal for full biological activity. The enzyme peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL; EC catalyzes the second and last step of this reaction, N-dealkylation of the peptidyl-alpha-hydroxyglycine to generate the alpha-amidated...
Brett Ronald Cutler et al.
International journal of cardiology, 261, 155-158 (2018-03-17)
Glycosaminoglycan (GAG), a major component of the endothelial glycocalyx, is severely perturbed in diabetic vasculature leading to endothelial inflammation and vascular disease in diabetes. We tested the hypothesis that blueberry metabolites (BBM) ameliorate endothelial inflammation in diabetic endothelial cells (ECs)...
R Kulathila et al.
Archives of biochemistry and biophysics, 311(1), 191-195 (1994-05-15)
The conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides occurs in two distinct reactions, both of which are catalyzed by bifunctional peptidylglycine alpha-amidating enzyme. The first step is the alpha-hydroxylation of the C-terminal glycine residue and the second step...

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