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224294

Sigma-Aldrich

Thiophosphoryl chloride

98%

Synonym(s):
Phosphorus thiochloride, Phosphorus sulfochloride
Linear Formula:
PSCl3
CAS Number:
Molecular Weight:
169.40
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

refractive index

n20/D 1.555 (lit.)

bp

125 °C (lit.)

mp

−35 °C (lit.)

solubility

benzene: soluble(lit.)
carbon disulfide: soluble(lit.)
carbon tetrachloride: soluble(lit.)
chloroform: soluble(lit.)

density

1.668 g/mL at 25 °C (lit.)

SMILES string

ClP(Cl)(Cl)=S

InChI

1S/Cl3PS/c1-4(2,3)5

InChI key

WQYSXVGEZYESBR-UHFFFAOYSA-N

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Application

Thiophosphoryl chloride was used in the synthesis of O-ethyl dichlorothiophosphate.

Packaging

100, 350 g in glass bottle
1.4 kg in glass bottle

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Sarah E Lee et al.
Chembiochem : a European journal of chemical biology, 12(4), 633-640 (2011-02-10)
The elucidation of signalling pathways relies heavily upon the identification of protein kinase substrates. Recent investigations have demonstrated the efficacy of chemical genetics using ATP analogues and modified protein kinases for specific substrate labelling. Here we combine N(6) -(cyclohexyl)ATPγS with...
J T Slama et al.
Analytical biochemistry, 209(1), 143-149 (1993-02-15)
Elemental [35S]sulfur was shown to equilibrate with the sulfur of thiophosphoryl chloride when these materials are heated together. This isotopic exchange reaction is the basis of a convenient, microscale synthesis of high specific activity [35S]PSCl3. [35S]Thiophosphoryl chloride is otherwise not...
Mohammed D Zidan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 58(8), 1577-1582 (2002-08-09)
A new route has been devised, leading to the production of phosphorus thiotrihalides, SPX3 where X = F, Br and I by an on-line process using phosphorus thiotrichloride, SPCl3 as starting compound gassed over the following heated salts NaF, KBr...
[Hygienic substantiation of the maximum permissible level of phosphorus thiotrichloride in reservoir water].
V M Tomkiv
Gigiena i sanitariia, (11)(11), 68-70 (1988-11-01)
D Coloşi-Esca et al.
Journal of applied toxicology : JAT, 4(5), 230-235 (1984-10-01)
The rat acute oral LD50 value of PSCl3 is 750 mg per kg body weight. A rat 90-day oral feeding study at dose levels of 7.5 mg (P1) and 37.5 mg (P5) per kg resulted in increased body weight gain....

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