1,2-Naphthoquinone-4-sulfonic acid sodium salt


3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level




289 °C (dec.) (lit.)


alcohol: slightly soluble 95%
acetone: moderately soluble(lit.)
benzene: insoluble(lit.)
carbon disulfide: insoluble(lit.)
chloroform: insoluble(lit.)
diethyl ether: insoluble(lit.)
petroleum ether: insoluble(lit.)
water: soluble(lit.)

SMILES string




InChI key


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1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.


10 g in glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react...
Linjin Ma et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(3), 599-602 (2011-05-03)
Boron determination by a charge transfer spectrophotometric method is described. Accompanied the reaction, a charge transfer complex can be formed by lysine with sodium 1, 2-naphthoquinone-4-sulfonate and boron in alkaline solution (pH 12.00). Subsequently, a new reaction mechanism has been...
Natividad García-Villar et al.
Electrophoresis, 27(2), 474-483 (2005-12-07)
A sensitive CE method for determining biogenic amines in wines based on in-capillary derivatization with 1,2-naphthoquinone-4-sulfonate is presented. In this method, reagent and buffer solutions are introduced hydrodynamically into the capillary whereas the sample is injected electrokinetically, thus, allowing a...
Ibrahim A Darwish et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(4), 897-902 (2009-01-13)
Spectrophotometric study was carried out, for the first time, to investigate the reaction between the antidepressant fluvoxamine (FXM) and 1,2-naphthoquinone-4-sulphonate (NQS) reagent. In alkaline medium (pH 9), an orange-colored product exhibiting maximum absorption peak (lambda(max)) at 470nm was produced. The...
Santiago Hernández-Cassou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(17-18), 1270-1281 (2010-12-28)
This paper revises the derivatization approaches for the determination of biogenic amines in wines. Since most of these amines display poor spectroscopic features to be detected by UV absorption or emission (fluorescence) spectroscopy, derivatization is necessary to attain the desired...

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