226904

Sigma-Aldrich

Methoxyamine hydrochloride

98%

Synonym(s):
O-Methylhydroxylamine hydrochloride, Methoxylamine hydrochloride
Linear Formula:
CH3ONH2 · HCl
CAS Number:
Molecular Weight:
83.52
Beilstein/REAXYS Number:
3589723
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

mp

151-154 °C (lit.)

solubility

alcohol: soluble(lit.)
water: soluble(lit.)

SMILES string

Cl.CON

InChI

1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H

InChI key

XNXVOSBNFZWHBV-UHFFFAOYSA-N

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General description

Methoxyamine hydrochloride combines with human antithrombin III-thrombin complex to form an inactive thrombin.

Application

Methoxyamine hydrochloride was used as a reagent in the preparation of O-methyl oximes. It was also used in the synthesis of O-methyl oximes from aldehydes or ketones.

Packaging

1, 5 g in glass bottle
25 g in poly bottle
100 g in glass bottle

Signal Word

Danger

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN3261 - class 8 - PG 2 - EHS - Corrosive solid, acidic, organic, n.o.s., HI: all

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

M O Longas et al.
The Biochemical journal, 189(3), 481-489 (1980-09-01)
1. Cleavage of the human antithrombin III--thrombin complex with [14C]methoxyamine hydrochloride results in inactive thrombin and 14C-labelled antithrombin III. 2. Discontinuous polyacrylamide-gel electrophoresis of the reduced dissociation fragments of the complex in the presence of sodium dodecyl sulphate reveals two...
The Journal of Organic Chemistry, 59, 1492-1492 (1994)
Synthesis, 849-849 (1992)
Edouard Godineau et al.
Organic letters, 8(21), 4871-4874 (2006-10-06)
[reaction: see text] A formal [2+2+2] process has been devised that allows the stereocontrolled formation of ring-fused piperidines from allylsilanes possessing an oxime moiety. The cascade involves an intermolecular radical addition of an alpha-iodoacetate onto an allylsilane double bond, which...
Tetrahedron Letters, 47, 6045-6045 (2006)
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