233226

2,4-Difluoronitrobenzene

99%

• Synonym(s): 2,4-Difluoro-1-nitrobenzene
• Linear Formula: F₂C₆H₃NO₂
• CAS Number: 446-35-5
• Molecular Weight: 159.09
• EC Number: 207-167-0
• MDL number: MFCD00007050
• PubChem Substance ID: 24853961
• NACRES: NA.22

Properties

• vapor density: >1 (vs air)
• Quality Level: 100
• assay: 99%
• form: liquid
• refractive index: n20/D 1.511 (lit.)
• bp: 203-204 °C (lit.)
• mp: 9-10 °C (lit.)
• density: 1.451 g/mL at 25 °C (lit.)
• SMILES string: [O-][N+](=O)c1ccc(F)cc1F
• InChI: 1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H
• InChI key: RJXOVESYJFXCGI-UHFFFAOYSA-N

Description

General description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

Application

2,4-Difluoronitrobenzene has been used in the synthesis of:

• 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
• (±)-horsfiline
• resin-bound 2-arylaminobenzimidazoles

Packaging

25, 100 g in glass bottle

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 - H315 - H319 - H335
• Precautionary Statements: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): 195.8 °F - closed cup
• Flash Point(C): 91 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves