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236314

Sigma-Aldrich

p-Toluidine

99.6%

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Synonym(s):
4-Aminotoluene, 4-Methylaniline
Linear Formula:
CH3C6H4NH2
CAS Number:
Molecular Weight:
107.15
Beilstein:
471281
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

vapor density

3.9 (vs air)

Quality Level

vapor pressure

0.26 mmHg ( 25 °C)
0.66 mmHg ( 38 °C)

Assay

99.6%

form

crystalline

autoignition temp.

899 °F

expl. lim.

6.6 %

pH

7.8 (7 g/L)

bp

200 °C (lit.)

mp

41-46 °C (lit.)

solubility

water: soluble 135 part(lit.)
acetone: freely soluble(lit.)
alcohol: freely soluble(lit.)
carbon disulfide: freely soluble(lit.)
diethyl ether: freely soluble(lit.)
methanol: freely soluble(lit.)
oil: freely soluble(lit.)

density

0.973 g/mL at 25 °C (lit.)

SMILES string

Cc1ccc(N)cc1

InChI

1S/C7H9N/c1-6-2-4-7(8)5-3-6/h2-5H,8H2,1H3

InChI key

RZXMPPFPUUCRFN-UHFFFAOYSA-N

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This Item
4611218.083151672053
p-Toluidine 99.6%

Sigma-Aldrich

236314

p-Toluidine

p-Toluidine 99%

Sigma-Aldrich

461121

p-Toluidine

p-Toluidine for synthesis

Sigma-Aldrich

8.08315

p-Toluidine

P-TOLUIDINE United States Pharmacopeia (USP) Reference Standard

USP

1672053

P-TOLUIDINE

vapor pressure

0.26 mmHg ( 25 °C), 0.66 mmHg ( 38 °C)

vapor pressure

1 hPa ( 42 °C), 7 hPa ( 68 °C)

vapor pressure

-

vapor pressure

-

assay

99.6%

assay

99%

assay

≥99.0% (GC)

assay

-

form

crystalline

form

powder, crystals or chunks

form

solid

form

-

autoignition temp.

899 °F

autoignition temp.

899 °F

autoignition temp.

899 °F

autoignition temp.

899 °F

expl. lim.

6.6 %

expl. lim.

6.6 %

expl. lim.

6.6 %

expl. lim.

6.6 %

General description

p-Toluidine undergoes oxidative coupling reaction with catecholamine to form an orange water-soluble dye during flow injection-spectrophotometric determination of catecholamine drugs.

Application

p-Toluidine has been used in preparation of:
  • aromatic azo compounds
  • bidentate Schiff base ligands via condensation with salicylaldehyde

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Skin Sens. 1A

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Flow injection-spectrophotometeric determination of some catecholamine drugs in pharmaceutical preparations via oxidative coupling reaction with< i> p</i>-toluidine and sodium periodate.
Abdulrahman LK, et al.
Analytica Chimica Acta, 538(1), 331-335 (2005)
Ruthenium (II) complexes containing bidentate Schiff bases and their antifungal activity.
Dharmaraj N, et al.
Transition Met. Chem. (London), 26(1-2), 105-109 (2001)
Abdessamad Grirrane et al.
Nature protocols, 5(3), 429-438 (2010-03-06)
This protocol describes the aerobic oxidation of aromatic anilines to aromatic azo compounds using gold (Au) nanoparticles supported on TiO(2) as a catalyst. Yields above 98% are achieved under a few bars of oxygen pressure. It should be noted that
J C Kennelly et al.
Mutation research, 137(1), 39-45 (1984-07-01)
The conventional Ames assay metabolising system was confirmed to be deficient in its ability to N-acetylate. This may render the test less sensitive to compounds which normally have an acetylation step during their in vivo activation to carcinogens. The addition
Paul G Stevenson et al.
Journal of chromatography. A, 1218(45), 8255-8263 (2011-10-11)
Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality

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