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MilliporeSigma

240311

Propionic anhydride

≥99%

Synonym(s):

Propanoic anhydride

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About This Item

Linear Formula:
(CH3CH2CO)2O
CAS Number:
123-62-6
Molecular Weight:
130.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24854413
EC Number:
204-638-2
Beilstein/REAXYS Number:
507066
MDL number:
MFCD00009303
Assay:
≥99%
Form:
liquid

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InChI key

WYVAMUWZEOHJOQ-UHFFFAOYSA-N

InChI

1S/C6H10O3/c1-3-5(7)9-6(8)4-2/h3-4H2,1-2H3

SMILES string

CCC(=O)OC(=O)CC

vapor density

4.5 (vs air)

vapor pressure

10 mmHg ( 57.7 °C)

assay

≥99%

form

liquid

autoignition temp.

545 °F

expl. lim.

11.9 %

Quality Level

200

bp

167 °C (lit.)

mp

−43 °C (lit.)

solubility

chloroform: soluble(lit.), diethyl ether: soluble(lit.), ethanol: soluble(lit.), methanol: soluble(lit.)

density

1.015 g/mL at 25 °C (lit.)

functional group

anhydride, ester

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1 of 4

This Item
81942P5147821580
Propionic anhydride ≥99%

Sigma-Aldrich

240311

Propionic anhydride

Propionic anhydride purum, ≥96.0% (NT)

Sigma-Aldrich

81942

Propionic anhydride

Propionic anhydride 97%

Sigma-Aldrich

P51478

Propionic anhydride

Hexanoic anhydride purum, ≥97.0% (GC)

Sigma-Aldrich

21580

Hexanoic anhydride

assay

≥99%

assay

≥96.0% (NT)

assay

97%

assay

≥97.0% (GC)

solubility

chloroform: soluble(lit.), ethanol: soluble(lit.), diethyl ether: soluble(lit.), methanol: soluble(lit.)

solubility

H2O: decomposes (when in contact with water)

solubility

H2O: decomposes (when in contact with water)

solubility

ethanol: soluble 1 g/10 mL, clear, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

bp

167 °C (lit.)

bp

167 °C (lit.)

bp

167 °C (lit.)

bp

246-248 °C (lit.)

form

liquid

form

liquid

form

-

form

liquid

refractive index

n20/D 1.404 (lit.)

refractive index

n20/D 1.404 (lit.)

refractive index

n20/D 1.404 (lit.)

refractive index

n20/D 1.428 (lit.), n20/D 1.429

Application

Propionic anhydride (propanoic anhydride) was used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate[1].

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

165.2 °F - closed cup

flash_point_c

74 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX2190
MKCV3767
MKCV2032
MKCS4636
MKCQ6610

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Mukundan Ragavan et al.
Metabolites, 11(7) (2021-08-07)
Type II diabetes and pre-diabetes are widely prevalent among adults. Elevated serum glucose levels are commonly treated by targeting hepatic gluconeogenesis for downregulation. However, direct measurement of hepatic gluconeogenic capacity is accomplished only via tracer metabolism approaches that rely on
F Compernolle et al.
The Biochemical journal, 125(3), 811-819 (1971-12-01)
1. The structures of the alpha(2)- and alpha(3)-azopigments, prepared by diazotization of dog bile with ethyl anthranilate, were shown by mass spectrometry and g.l.c. to correspond to azobilirubin beta-d-xylopyranoside and azobilirubin beta-d-glucopyranoside respectively. 2. Both azopigments consist of a mixture
Robert Meatherall et al.
Journal of analytical toxicology, 33(8), 525-531 (2009-10-31)
Azide in human blood and plasma samples was derivatized with propionic anhydride in a headspace vial without prior sample preparation. The reaction proceeds quickly at room temperature to form propionyl azide. A portion of the headspace was assayed by gas
Surendra Nimesh et al.
International journal of pharmaceutics, 337(1-2), 265-274 (2007-01-27)
Polyethylenimine (750 kDa) has been derivatized to influence the proton sponge mechanism and hydrophobic-hydrophilic balance. The polymer was acylated using acid anhydrides of varying carbon chain length, followed by cross-linking with PEG-bis-P to form compact nanoparticles. The chemical linkages in
Haim Tsubery et al.
The Journal of biological chemistry, 279(37), 38118-38124 (2004-06-11)
Polyethylene glycol (PEG)-conjugated therapeutic peptides/proteins have been shown to exhibit clinical properties superior to those of their corresponding unmodified parent molecules. However, the desirable pharmacological features gained by protein PEGylation become irrelevant if conjugates are inactivated or cannot reach their
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. could you provide Grade of the propinicanhydride

    1 answer

    1. This is a research-grade product. It is used as an organic building block in organic synthesis. This product is assigned a quality level of 200. It is intended for research use only. For more information regarding the quality levels within the M-Clarity program see the link below:
      https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/m-clarity-program

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