244929

Sigma-Aldrich

Dichloro(ethylenediamine)platinum(II)

99%

Synonym(s):
Dichloro(1,2-ethanediamine)platinum, Dichloro(1,2-diaminoethane)platinum, Platinum ethylenediamine dichloride
Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
Molecular Weight:
326.08
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

99%

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

ClPtCl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-37/39

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

S Isonishi et al.
British journal of cancer, 69(2), 217-221 (1994-02-01)
Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was...
P Naredi et al.
The Journal of clinical investigation, 95(3), 1193-1198 (1995-03-01)
Cross-resistance between cisplatin (DDP) and metalloid salts in human cells was sought on the basis that mechanisms that mediate metalloid salt cross-resistance in prokaryotes are evolutionarily conserved. Two ovarian and two head and neck carcinoma cell lines selected for DDP...
R Jamshidipour et al.
Cancer chemotherapy and pharmacology, 34(6), 484-490 (1994-01-01)
Cholecystokinin (CCK) is an important trophic hormone for the pancreas, and CCK receptors are present on pancreatic carcinoma cells. We sought to determine whether either CCK itself or an antagonist of CCK could modulate the sensitivity of the human pancreatic...
A P Jekunen et al.
Biochemical pharmacology, 45(10), 2079-2085 (1993-05-25)
Killing of human ovarian carcinoma 2008 cells by cisplatin (DDP) is in direct proportion to the amount of drug entering the cell. DDP and its analogue [3H]dichloro(ethylenediamine)platinum[II] ([3H]-DEP) enter cells relatively slowly. We found that the uptake of [3H]DEP into...
P Mailliet et al.
Anti-cancer drug design, 10(1), 51-73 (1995-01-01)
A series of platinum dichloroethylenediamine complexes [PtCl2(R-en)] bearing a side chain on one carbon atom of the ethylenediamine ligand, with or without a functional group on the side chain, have been prepared and investigated for antitumor activity against L1210 leukemia....

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