248509

Sigma-Aldrich

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution

0.1 M in methylene chloride

Synonym(s):
TPC, (S)-(−)-N-(Trifluoroacetyl)prolyl chloride solution
Empirical Formula (Hill Notation):
C7H7ClF3NO2
CAS Number:
Molecular Weight:
229.58
Beilstein/REAXYS Number:
480791
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

optical purity

ee: 97% (GLC)

Quality Level

concentration

0.1 M in methylene chloride

refractive index

n20/D 1.424

density

1.308 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)N1CCCC@H1C(Cl)=O

InChI

1S/C7H7ClF3NO2/c8-5(13)4-2-1-3-12(4)6(14)7(9,10)11/h4H,1-3H2/t4-/m0/s1

InChI key

NUOYJPPISCCYDH-BYPYZUCNSA-N

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Application

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride can be used as a chiral derivatization reagent:
  • In the chiral separation of psychoactive, cathinone- and amphetamine-related drugs using GC-MS technique.
  • In the estimation of cathinone related drug enantiomers in biological samples like urine and plasma using GC-MS technique.

Packaging

5, 25 g in glass bottle

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Target Organs

Central nervous system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

36/37/38-40-67

Safety Statement

26-36/37

RIDADR

UN 1593 6.1 / PGIII

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Junsheng Yang et al.
Protein & cell, 10(1), 8-19 (2018-03-20)
Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life, ranging from cell proliferation to cell death, in a spatially and temporally regulated manner. A key aspect of this regulation is the compartmentalization of Ca2+ in various...
Chiral separation of new cathinone-and amphetamine-related designer drugs by gas chromatography-mass spectrometry using trifluoroacetyl-l-prolyl chloride as chiral derivatization reagent
Mohr S, et al.
Journal of Chromatography A, 1269(3), 352-359 (2012)
José Luis Ros-Santaella et al.
PloS one, 12(8), e0183682-e0183682 (2017-08-25)
Rooibos (Aspalathus linearis) is a native shrub from South African fynbos and has become very popular in the last decades for its antioxidant and medicinal attributes. Several studies have shown its beneficial properties in numerous cell lines, but to date...
Laura Cacciamani et al.
Frontiers in aging neuroscience, 9, 291-291 (2017-10-03)
The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole...
Qiao Feng Tao et al.
Journal of biochemical and biophysical methods, 54(1-3), 103-113 (2003-01-25)
Several important chiral phenethylamine agents such as mexiletine, fenfluramine, amphetamine, methamphetamine and N-n-propylamphetamine show stereoselective disposition in humans and large differences in therapeutic relevance and toxicity. To analyze the enantiomers of chiral amine drugs, stereoselective methods were developed to separate...

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