249475

Sigma-Aldrich

4-(Trifluoromethyl)benzoyl chloride

97%

Synonym(s):
α,α,α-Trifluoro-p-toluoyl chloride
Linear Formula:
CF3C6H4COCl
CAS Number:
Molecular Weight:
208.56
Beilstein/REAXYS Number:
391282
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

97%

refractive index

n20/D 1.476 (lit.)

bp

188-190 °C (lit.)
78-79 °C/16 mmHg (lit.)

density

1.404 g/mL at 25 °C (lit.)

SMILES string

FC(F)(F)c1ccc(cc1)C(Cl)=O

InChI

1S/C8H4ClF3O/c9-7(13)5-1-3-6(4-2-5)8(10,11)12/h1-4H

InChI key

OXZYBOLWRXENKT-UHFFFAOYSA-N

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General description

4-(Trifluoromethyl)benzoyl chloride undergoes microwave-promoted Suzuki-type coupling reaction with phenylboronic acid to yield 4-(trifluoromethyl)benzophenone.

Packaging

1, 5, 25 g in ampule

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 3265 8 / PGII

WGK Germany

WGK 3

Flash Point(F)

172.4 °F - closed cup

Flash Point(C)

78 °C - closed cup

Microwave-promoted cross-coupling of acid chlorides with arylboronic acids: a convenient method for preparing aromatic ketones.
Polackova V, et al.
Tetrahedron, 62(50), 11675-11678 (2006)
Risa Iima et al.
AAPS PharmSciTech, 19(6), 2679-2686 (2018-06-27)
We developed carriers of a 19F magnetic resonance imaging (19F MRI) agent, capable of responding to the temperature difference for cancer diagnosis. The carriers were based on high melting point (mp) neutral lipids, namely, tripalmitin (TPT) and tristearin (TSR) and...

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