255068

Sigma-Aldrich

Tris(methylthio)methane

98%

Synonym(s):
Trimethyl trithioorthoformate
Linear Formula:
(CH3S)3CH
CAS Number:
Molecular Weight:
154.32
Beilstein/REAXYS Number:
1733825
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

98%

refractive index

n20/D 1.577 (lit.)

bp

102 °C/15 mmHg (lit.)
225-227 °C (lit.)

mp

16 °C (lit.)

density

1.16 g/mL at 25 °C (lit.)

SMILES string

CSC(SC)SC

InChI

1S/C4H10S3/c1-5-4(6-2)7-3/h4H,1-3H3

InChI key

YFMZQCCTZUJXEB-UHFFFAOYSA-N

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General description

Tris(methylthio)methane is a carboxylic anion equivalent.

Application

Tris(methylthio)methane has been used in synthesis of:
  • (−)-nephrosteranic acid and (−)-roccellaric acid
  • (4R,5R)-5-({1-(tert-butyl)-1,1-diphenylsilyloxy}methyl)4-tri(methylthio)methyltetrahydro-furan-2-one
  • terminal difluoromethylenes

Packaging

5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

UN 3334

WGK Germany

WGK 3

Flash Point(F)

186.8 °F - closed cup

Flash Point(C)

86 °C - closed cup

From ketones, aldehydes or alkyl halides to terminal 1, 1-difluoroolefins using BrF3.
Hagooly A and Rozen S.
Journal of Fluorine Chemistry, 126(8), 1239-1245 (2005)
Bin Mao et al.
Organic letters, 13(5), 948-951 (2011-01-28)
An efficient catalytic asymmetric synthesis of chiral γ-butenolides was developed based on the hetero-allylic asymmetric alkylation (h-AAA) in combination with ring closing metathesis (RCM). The synthetic potential of the h-AAA-RCM protocol was illustrated with the facile synthesis of (-)-whiskey lactone...
Claudia Mugnaini et al.
Bioorganic & medicinal chemistry, 11(3), 357-366 (2003-01-09)
Novel nucleoside analogues of both D and L enantiomeric series were prepared by coupling reaction between a 2',3'-dideoxy-3'-modified furanose moiety and four different nucleobases. Though in all cases anomeric mixtures of nucleosides were obtained, the presence of the sterically bulky...

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