All Photos(3)

256439

Sigma-Aldrich

4,4′-Methylenebis(phenyl isocyanate)

98%

Synonym(s):
4,4′-MDI, Bis(4-isocyanatophenyl)methane
Linear Formula:
CH2(C6H4NCO)2
CAS Number:
Molecular Weight:
250.25
Beilstein:
797662
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

98%

reaction suitability

reagent type: cross-linking reagent

bp

200 °C/5 mmHg (lit.)

mp

42-45 °C (lit.)

density

1.18 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1

InChI

1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2

InChI key

UPMLOUAZCHDJJD-UHFFFAOYSA-N

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Packaging

50, 500 g in glass bottle
5 kg in poly drum

Application

Uses include UV curable and latent catalyst-containing polymerization compositions.

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

411.8 °F - closed cup

Flash Point(C)

211 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Journal of Applied Physiology, 70, 6983-6983 (1991)
Hanna K Lindberg et al.
Mutation research, 723(1), 1-10 (2011-04-02)
Toluene diisocyanate (TDI) and 4,4'-methylenediphenyl diisocyanate (MDI), used in the production of polyurethane foam, are well known for their irritating and sensitizing properties. Contradictory results have been obtained on their genotoxicity. We investigated the genotoxicity and protein binding of inhaled...
Unique foreign body ingestions in the pediatric population.
Sheila Isabelle Goertemoeller et al.
Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association, 36(2), 178-179 (2010-03-10)
Dominika Swierczyńska-Machura et al.
Medycyna pracy, 62(6), 567-577 (2012-02-09)
The aim of the study was to analyze the data obtained during the diagnostic process and their real values in the final diagnosis of patients exposed to diisocyanates amd suspected of occupational allergic disease of the respiratory system The patients...
Anoop Kumar et al.
Chemical research in toxicology, 22(12), 1975-1983 (2009-11-26)
4,4'-Methylenediphenyl diisocyanate (MDI) is the most important of the isocyanates used as intermediates in the chemical industry. Among the main types of damage after exposure to low levels of MDI are lung sensitization and asthma. Albumin adducts of MDI might...

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